The TLR4-TRIF-type 1 IFN-IFN-gamma pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection

Yamamoto, Koji; Kondo, Yasuyuki; Ohnishi, Shunsuke; Yoshida, Masaru; Sugiyama, Toshiro; Sakamoto, Naoya

The TLR4-TRIF-type 1 IFN-IFN-gamma pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection

Yamamoto, Koji; Kondo, Yasuyuki; Ohnishi, Shunsuke et al.

iScience, 2021, 24(9), 103064

Permalink : https://hdl.handle.net/2115/83247

このアイテムのアクセス数:478件（2026-10-14 12:47 集計）

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https://doi.org/10.1016/j.isci.2021.103064			15

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83247
タイトル	The TLR4-TRIF-type 1 IFN-IFN-gamma pathway is crucial for gastric MALT lymphoma formation after Helicobacter suis infection
著者	Yamamoto, Koji ; Kondo, Yasuyuki ; Ohnishi, Shunsuke ; Yoshida, Masaru ; Sugiyama, Toshiro ; Sakamoto, Naoya
e-Rad_Researcher 70608322 著者名 Yamamoto, Koji
著者名 Kondo, Yasuyuki
e-Rad_Researcher 10443475 著者名 Ohnishi, Shunsuke
著者名 Yoshida, Masaru
著者名 Sugiyama, Toshiro
e-Rad_Researcher 10334418 著者名 Sakamoto, Naoya
言語	英語
発行日	2021-09-24
出版者	Cell Press
収録物名	iScience
巻(号)	24(9)
ページ	103064
抄録	Helicobacter suis, a zoonotic infection-related bacterium, can induce gastric mucosa-associated lymphoid tissue (MALT) lymphoma in humans and animals. Recently, we reported that the formation of gastric MALT lymphoma after H. suis infection is induced by interferon (IFN)-gamma activation. Here, we revealed that activation of the Toll-like receptor (TLR) 4-Toll/IL-1 receptor domain-containing adapter-inducing interferon-beta (TRIF) pathway after H. suis infection is associated with the production of type 1 IFNs (IFN-alpha, IFN-beta) by gastric epithelial cells. Additionally, these type 1 IFNs interact with type 1 IFN receptors on gastric B cells, facilitating the secretion of IFN-gamma and the activation of which is enhanced by positive feedback regulation in B cells. These results suggest that the TLR4-TRIF-type 1 IFN-IFN-gamma pathway is crucial in the development of gastric MALT lymphoma after H. suis infection and may, therefore, represent a therapeutic target for the prevention of this condition.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.isci.2021.103064