Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23

Suzuki, Hiroe; Otsuka, Takahisa; Hitora-Imamura, Natsuko; Ishimura, Kohei; Fukuda, Hayato; Fujiwara, Koichi; Shuto, Satoshi; Deyama, Satoshi; Minami, Masabumi

Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23

Suzuki, Hiroe; Otsuka, Takahisa; Hitora-Imamura, Natsuko et al.

Biological & pharmaceutical bulletin, 2021, 44(10), 1548-1550

Permalink : https://hdl.handle.net/2115/83324

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https://doi.org/10.1248/bpb.b21-00461			37

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83324
タイトル	Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23
著者	Suzuki, Hiroe ; Otsuka, Takahisa ; Hitora-Imamura, Natsuko ; Ishimura, Kohei ; Fukuda, Hayato ; Fujiwara, Koichi ; Shuto, Satoshi ; Deyama, Satoshi ; Minami, Masabumi
著者名 Suzuki, Hiroe
著者名 Otsuka, Takahisa
著者名 Hitora-Imamura, Natsuko
著者名 Ishimura, Kohei
著者名 Fukuda, Hayato
e-Rad_Researcher 40837853 著者名 Fujiwara, Koichi
e-Rad_Researcher 70241346 著者名 Shuto, Satoshi
e-Rad_Researcher 30634993 著者名 Deyama, Satoshi
e-Rad_Researcher 20243040 著者名 Minami, Masabumi
言語	英語
キーワード	resolvin
	n-3 polyunsaturated fatty acid
	antidepressant
	pain
発行日	2021-10-01
出版者	The Pharmaceutical Society of Japan （日本薬学会）
収録物名	Biological & pharmaceutical bulletin
巻(号)	44(10)
ページ	1548-1550
抄録	The antidepressant effect of eicosapentaenoic acid-derived bioactive lipid, resolvin E1 (RvE1), was examined in a murine model of chronic pain-induced depression using a tail suspension test. Because RvE1 reportedly possesses agonistic activity on a chemerin receptor ChemR23, we also examined the antidepressant effect of chemerin. Two weeks after surgery for unilateral spared nerve injury to prepare neuropathic pain model mice, immobility time was measured in a tail suspension test. Chronic pain significantly increased immobility time, and this depression-like behavior was attenuated by intracerebroventricular injection of RvE1 (1 ng) or chemerin (500 ng). These results demonstrate that RvE1 exerts an antidepressant effect in a murine model of chronic pain-induced depression, which is likely to be via ChemR23. RvE1 and its receptor may be promising targets to develop novel antidepressants.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-6158
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/bpb.b21-00461