Identification of ACE inhibitory peptides from red alga Mazzaella japonica

Kumagai, Yuya; Kitade, Yumi; Kobayashi, Manami; Watanabe, Kei; Kurita, Hiroki; Takeda, Hirohumi; Yasui, Hajime; Kishimura, Hideki

Identification of ACE inhibitory peptides from red alga Mazzaella japonica

Kumagai, Yuya; Kitade, Yumi; Kobayashi, Manami et al.

European Food Research and Technology, 2021, 246, 2225-2231

Permalink : https://hdl.handle.net/2115/83358

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83358
タイトル	Identification of ACE inhibitory peptides from red alga Mazzaella japonica
著者	Kumagai, Yuya ; Kitade, Yumi ; Kobayashi, Manami ; Watanabe, Kei ; Kurita, Hiroki ; Takeda, Hirohumi ; Yasui, Hajime ; Kishimura, Hideki
e-Rad_Researcher 00589997 著者名 Kumagai, Yuya
著者名 Kitade, Yumi
著者名 Kobayashi, Manami
著者名 Watanabe, Kei
著者名 Kurita, Hiroki
著者名 Takeda, Hirohumi
e-Rad_Researcher 00200494 著者名 Yasui, Hajime
e-Rad_Researcher 50204855 著者名 Kishimura, Hideki
言語	英語
キーワード	ACE inhibitory activity
	Antihypertension
	Red alga
	Mazzaella japonica
	Protein hydrolysate
発行日	2021-11-30
出版者	Springer
収録物名	European Food Research and Technology
巻(号)	246
ページ	2225-2231
抄録	Angiotensin I converting enzyme (ACE) inhibition is one of the key factors for cardiovascular disease, and inhibition of ACE activity is related to the prevention of high blood pressure. Until now, some ACE inhibitory peptides have been found in the protein hydrolysates of red algae, and most of them were derived from phycobiliproteins and rubisco. In this study, we modified the preparation method to evaluate the potential of ACE inhibitory activity from protein hydrolysate of red algaMazzaella japonicaexcept for phycobiliproteins and rubisco. As a result, we identified 11 peptides (YRD, VSEGLD, TIMPHPR, GGPAT, SSNDYPI, SRIYNVKSNG, VDAHY, CPYDWV, YGDPDHY, NLGN and DFGVPGHEP) in the hydrolysate by the reversed phase-HPLC and MALDI-TOF/MS/MS. Among them, YRD would be derived from phycoerythrin alpha-subunit. However, the others would be from other proteins encoded in chloroplast or nuclear genomes. This study revealed that not only phycobiliproteins and rubisco but also the other proteins in red algae have the potential for the source of ACE inhibitory peptide.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in European Food Research and Technology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00217-020-03567-z
PISSN	1438-2377
NCID	AA11399927
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00217-020-03567-z