Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans

Wakabayashi, Hitoshi; Matsumoto, Kentaro; Kobori, Yusuke; Ebara, Tasuku; Matsushita, Mami; Kameya, Toshimitsu; Maeda, Takafumi; Saito, Masayuki

Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans

Wakabayashi, Hitoshi; Matsumoto, Kentaro; Kobori, Yusuke et al.

European journal of applied physiology, 2020, 120(12), 2737-2747

Permalink : https://hdl.handle.net/2115/83362

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アクセス権	open access
URI	https://hdl.handle.net/2115/83362
タイトル	Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans
著者	Wakabayashi, Hitoshi ; Matsumoto, Kentaro ; Kobori, Yusuke ; Ebara, Tasuku ; Matsushita, Mami ; Kameya, Toshimitsu ; Maeda, Takafumi ; Saito, Masayuki
著者名 Wakabayashi, Hitoshi
著者名 Matsumoto, Kentaro
著者名 Kobori, Yusuke
著者名 Ebara, Tasuku
著者名 Matsushita, Mami
著者名 Kameya, Toshimitsu
著者名 Maeda, Takafumi
e-Rad_Researcher 80036441 著者名 Saito, Masayuki
言語	英語
キーワード	Brown adipose tissue
	Skeletal muscle
	Cold-induced thermogenesis
	Whole-body contribution
発行日	2020-12
出版者	Springer
収録物名	European journal of applied physiology
巻(号)	120(12)
ページ	2737-2747
抄録	Purpose Human brown adipose tissue (BAT) is known to be a significant thermoeffector in non-shivering thermogenesis (NST), albeit with individual variations in the BAT activity. We hypothesized that humans with less BAT would have more contribution from the skeletal muscle (SM) to NST or earlier shivering onset and greater vasoconstriction to compensate for less BAT-mediated thermogenesis. Methods Eighteen males participated in this study. Their BAT activity and detectable volume were investigated. A gradual cold exposure was conducted for inducing NST at 18.6 degrees C and initiating shivering at 11.6 degrees C. The energy expenditure, electromyograph of the pectoralis major, skin blood flow, and rectal (T-re) and skin temperatures were evaluated. Results BAT volume significantly correlated with the change in metabolic heat production during mild cold phase relative to baseline (NST;r = 0.562,P < 0.05), but not with shivering initiation phase (NST+ ST). SM mass correlated with baseline metabolic heat production (M-base;r = 0.839,P < 0.01) but not withNSTorNST + ST. A positive correlation was noted between BAT volume andT(re)at the end of the 18.6 degrees C exposure period (r = 0.586,P < 0.05), which positively correlated with shivering onset time (r = 0.553,P < 0.05). The skin blood flow, mean skin temperature, and forearm and finger skin temperature difference at the end of the 18.6 degrees C exposure period did not correlate withNSTor BAT volume. Conclusion BAT volume positively correlated withNST. Notably, lowerT(re)in individuals with less BAT volume induced earlier shivering onset for offsetting the lessNST. Whereas, no correlation between metabolic and vasomotor responses was observed.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in European Journal of Applied Physiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00421-020-04496-1
PISSN	1439-6319
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00421-020-04496-1