Research Note : Characterization of S-Meq containing the deletion in Meq protein's transactivation domain in a Marek's disease virus strain in Japan

Murata, Shiro; Yamamoto, Eiji; Sakashita, Natsumi; Maekawa, Naoya; Okagawa, Tomohiro; Konnai, Satoru; Ohashi, Kazuhiko

Research Note : Characterization of S-Meq containing the deletion in Meq protein's transactivation domain in a Marek's disease virus strain in Japan

Murata, Shiro; Yamamoto, Eiji; Sakashita, Natsumi et al.

Poultry Science, 2021, 100(11), 101461

Permalink : https://hdl.handle.net/2115/83382

このアイテムのアクセス数:396件（2026-08-09 01:00 集計）

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https://doi.org/10.1016/j.psj.2021.101461			9

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83382
タイトル	Research Note : Characterization of S-Meq containing the deletion in Meq protein's transactivation domain in a Marek's disease virus strain in Japan
著者	Murata, Shiro ; Yamamoto, Eiji ; Sakashita, Natsumi ; Maekawa, Naoya ; Okagawa, Tomohiro ; Konnai, Satoru ; Ohashi, Kazuhiko
e-Rad_Researcher 10579163 著者名 Murata, Shiro
著者名 Yamamoto, Eiji
著者名 Sakashita, Natsumi
e-Rad_Researcher 70829035 著者名 Maekawa, Naoya
e-Rad_Researcher 80829036 著者名 Okagawa, Tomohiro
e-Rad_Researcher 40396304 著者名 Konnai, Satoru
e-Rad_Researcher 90250498 著者名 Ohashi, Kazuhiko
言語	英語
キーワード	deletion
	Marek's disease virus
	Meq
	S-Meq
	transactivation
発行日	2021-11-01
出版者	Elsevier
収録物名	Poultry Science
巻(号)	100(11)
ページ	101461
抄録	Marek's disease virus (MDV) causes malignant lymphomas in chickens (Marek's disease; MD). Although MD has caused significant economic losses to the poultry industry, currently, its occurrence in the field is effectively controlled by vaccination. However, the genetic characteristics of MDV strains have changed, and the poultry industry has experienced MD outbreaks in vaccinated chickens because of enhanced virulence. Meq, an oncoprotein of MDV, is a key transcription factor correlated with the tumorigenesis in MD. Animal experiments using recombinant MDV revealed that distinct polymorphisms in Meq affect the virulence of MDV strains. Meq containing an insertion or deletion is present in some MDV strains. In the 2010s, field strains that encode Meq containing the deletion (S-Meq) were reported. In this study, we characterized the genetic features of S-Meq detected in a Japanese MDV strain and analyzed its transactivation activity to investigate S-Meq's protein function. S-Meq lacked 41 amino acids, and the deletion was at the same position as those observed in other countries. In addition, S-Meq exhibited higher transactivation activity than Meq from other MDV strains circulating in Japan. These results suggest that the deletion in the transactivation domain may enhance the Meq protein's function. Further investigation is needed to clarify whether the deletion in the transactivation domain of Meq affects MDV's virulence.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.psj.2021.101461