Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis

Takeuchi, Sora; Kawakami, Tamihiro; Okano, Tatsuro; Shida, Haruki; Nakazawa, Daigo; Tomaru, Utano; Ishizu, Akihiro; Kadono, Takafumi

Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis

Takeuchi, Sora; Kawakami, Tamihiro; Okano, Tatsuro et al.

Pathobiology, 2021, 89(1), 23-28

Permalink : https://hdl.handle.net/2115/83384

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アクセス権	open access
URI	https://hdl.handle.net/2115/83384
タイトル	Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis
著者	Takeuchi, Sora ; Kawakami, Tamihiro ; Okano, Tatsuro ; Shida, Haruki ; Nakazawa, Daigo ; Tomaru, Utano ; Ishizu, Akihiro ; Kadono, Takafumi
著者名 Takeuchi, Sora
著者名 Kawakami, Tamihiro
著者名 Okano, Tatsuro
著者名 Shida, Haruki
e-Rad_Researcher 60724135 著者名 Nakazawa, Daigo
e-Rad_Researcher 20360901 著者名 Tomaru, Utano
e-Rad_Researcher 60321957 著者名 Ishizu, Akihiro
著者名 Kadono, Takafumi
言語	英語
キーワード	IgA vasculitis
	Neutrophil extracellular traps
	Antineutrophil cytoplasmic antibody
	Renal complications
発行日	2021-11-23
出版者	Karger
収録物名	Pathobiology
巻(号)	89(1)
ページ	23-28
抄録	Introduction: IgA vasculitis is a systemic disease that results from the entrapment of circulating IgA-containing immune complexes in small-vessel walls in the skin, kidneys, and gastrointestinal tract. An excessive formation of neutrophil extracellular traps (NETs) is involved in the pathogenesis of vasculitis, especially in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This study aimed to clarify whether NETs are implicated in IgA vasculitis. Methods: Twenty-two patients with IgA vasculitis and 4 healthy volunteers were enrolled in this study. Serum levels of myeloperoxidase (MPO)-DNA complex, a fragment derived from NETs, were determined by enzyme-linked immunosorbent assay (ELISA), and the association between MPO-DNA complex levels and clinical parameters was examined. The presence of the ANCA was also assessed by ELISA specific for MPO and proteinase 3 (PR3) and indirect immunofluorescence (IIF), followed by assessing the differences in clinical parameters with and without the ANCA. Results: Serum MPO-DNA complex levels were significantly higher in patients with IgA vasculitis than those in healthy controls. A significant positive correlation between the serum MPO-DNA complex and IgA levels was noted. Interestingly, 63.6% of IgA vasculitis patients were ANCA-positive in IIF with an atypical pattern, whereas neither MPO-ANCA nor PR3-ANCA was detected by ELISA. These findings indicated that some IgA vasculitis patients possessed the so called minor ANCA. Serum IgA and MPO-DNA complex levels and the frequency of hematuria in the minor ANCA-positive group were significantly higher than in the minor ANCA-negative group. Conclusion: The collective findings suggested that NETs are certainly involved in the pathogenesis of IgA vasculitis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1015-2008
EISSN	1423-0291
関連情報	PMID 34814154
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1159/000519869