Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease

Osuga, Tatsuyuki; Morita, Tomoya; Sasaki, Noboru; Morishita, Keitaro; Ohta, Hiroshi; Takiguchi, Mitsuyoshi

Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease

Osuga, Tatsuyuki; Morita, Tomoya; Sasaki, Noboru et al.

Journal of Veterinary Internal Medicine, 2021, 35(6), 2607-2615

Permalink : https://hdl.handle.net/2115/83491

このアイテムのアクセス数:529件（2026-08-17 05:28 集計）

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https://doi.org/10.1111/jvim.16290			38

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アクセス権	open access
URI	https://hdl.handle.net/2115/83491
タイトル	Prognostic value of left ventricular-arterial coupling estimated using echocardiography in dogs with myxomatous mitral valve disease
著者	Osuga, Tatsuyuki ; Morita, Tomoya ; Sasaki, Noboru ; Morishita, Keitaro ; Ohta, Hiroshi ; Takiguchi, Mitsuyoshi
著者名 Osuga, Tatsuyuki
著者名 Morita, Tomoya
e-Rad_Researcher 00754532 著者名 Sasaki, Noboru
e-Rad_Researcher 30637046 著者名 Morishita, Keitaro
e-Rad_Researcher 50431333 著者名 Ohta, Hiroshi
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
言語	英語
キーワード	canine
	Ea
	Ees
	elastance
	mitral regurgitation
	survival time
発行日	2021-11-06
出版者	John Wiley & Sons
収録物名	Journal of Veterinary Internal Medicine
巻(号)	35(6)
ページ	2607-2615
抄録	Background The interaction between the left ventricle (LV) and systemic arterial systems, known as left ventricular-arterial coupling (VAC), has been evaluated based on the effective arterial elastance (Ea) to LV end-systolic elastance (Ees) ratio (Ea/Ees). The Ea reflects the total arterial load of LV, whereas Ees reflects the LV systolic function. A recent study found that inappropriate VAC based on increased Ea/Ees estimated by echocardiography is associated with advanced disease severity in dogs with myxomatous mitral valve disease (MMVD). Hypothesis Inappropriate VAC assessed by echocardiographic estimation of Ea/Ees is associated with a worse prognosis in dogs with MMVD. Animals Eighty-nine dogs with MMVD. Methods Prospective cohort study. Dogs underwent echocardiographic examinations at enrollment. The Ea was estimated using the formula: mean blood pressure/(forward stroke volume/body weight). The Ees was estimated using the formula: mean blood pressure/(LV end-systolic volume/body weight). The Ea/Ees was calculated. Results By end of study, 22 dogs died of cardiac-related causes with 67 dogs censored. Dogs with increased Ea/Ees (Ea/Ees >0.34; median survival time, 527 days; 95% confidence interval [CI], 322 days-not determinable) had a shorter survival time (P < .0001) than those without increased Ea/Ees (Ea/Ees <= 0.34; median survival time, >1112 days; 95% CI, not determinable). Multivariate Cox proportional hazard analysis showed that Ea/Ees, body weight, peak systolic mitral annular velocity, and the peak early diastolic transmitral velocity-to-peak early diastolic mitral annular velocity ratio were independent predictors of cardiac-related death among echocardiographic indices. Conclusions and Clinical Importance Inappropriate VAC assessed based on echocardiographically-estimated Ea/Ees is associated with a worse prognosis in dogs with MMVD.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0891-6640
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/jvim.16290