A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy

Fukunaga, Hisanori; Butterworth, K. T.; McMahon, S. J.; Prise, K. M.

A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy

Fukunaga, Hisanori; Butterworth, K. T.; McMahon, S. J. et al.

Clinical Oncology, 2021, 33(11), 705-712

Permalink : https://hdl.handle.net/2115/83647

このアイテムのアクセス数:366件（2026-01-14 06:31 集計）

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https://doi.org/10.1016/j.clon.2021.08.011			2

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/83647
タイトル	A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy
著者	Fukunaga, Hisanori ; Butterworth, K. T. ; McMahon, S. J. ; Prise, K. M.
e-Rad_Researcher 50781267 著者名 Fukunaga, Hisanori
著者名 Butterworth, K. T.
著者名 McMahon, S. J.
著者名 Prise, K. M.
言語	英語
キーワード	Bystander effects
	grid therapy
	microbeam radiotherapy
	vascular damage
発行日	2021-11
出版者	Elsevier
収録物名	Clinical Oncology
巻(号)	33(11)
ページ	705-712
抄録	Microbeam radiotherapy (MRT) is the delivery of spatially fractionated beams that have the potential to offer significant improvements in the therapeutic ratio due to the delivery of micron-sized high dose and dose rate beams. They build on longstanding clinical experience of GRID radiotherapy and more recently lattice-based approaches. Here we briefly overview the preclinical evidence for MRT efficacy and highlight the challenges for bringing this to clinical utility. The biological mechanisms underpinning MRT efficacy are still unclear, but involve vascular, bystander, stem cell and potentially immune responses. There is probably significant overlap in the mechanisms underpinning MRT responses and FLASH radiotherapy that needs to be further defined. (c) 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0936-6555
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.clon.2021.08.011