Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US

Yamazaki, Hiroyuki; Wada, Tsuneyuki; Asano, Hiroshi; Fujita, Hiromasa; Okamoto, Kazuhira; Watari, Hidemichi

Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US

Yamazaki, Hiroyuki; Wada, Tsuneyuki; Asano, Hiroshi et al.

Diagnostics, 2021, 11(10), 1895

Permalink : https://hdl.handle.net/2115/83660

このアイテムのアクセス数:588件（2026-01-18 16:21 集計）

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https://doi.org/10.3390/diagnostics11101895

論文情報

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/83660
タイトル	Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US
著者	Yamazaki, Hiroyuki ; Wada, Tsuneyuki ; Asano, Hiroshi ; Fujita, Hiromasa ; Okamoto, Kazuhira ; Watari, Hidemichi
著者名 Yamazaki, Hiroyuki
著者名 Wada, Tsuneyuki
著者名 Asano, Hiroshi
著者名 Fujita, Hiromasa
著者名 Okamoto, Kazuhira
e-Rad_Researcher 10344508 著者名 Watari, Hidemichi
言語	英語
キーワード	uterine cervical neoplasms
	human papillomavirus DNA tests
	early detection of cancer
	atypical squamous cells of the cervix
	urinalysis
発行日	2021-10
出版者	MDPI
収録物名	Diagnostics
巻(号)	11(10)
ページ	1895
抄録	Most uterine cervical cancers are caused by the persistent infection of the high-risk human papillomavirus (hrHPV). Thus, the hrHPV-DNA test, which examines specimens from the cervix, is the standard screening method as well as cytology in western countries. Urine sampling for the hrHPV-DNA test would be easier and help improving screening rates. This study prospectively investigated the concordance between urine and cervical hrHPV tests for patients with atypical squamous cells of undetermined significance (ASC-US) in cervical cytology. We recruited 338 women with the cytologic diagnosis of ASC-US and performed hrHPV-DNA tests to both samples from the uterine cervix and first void urine, using the Cobas 4800 system. In all hrHPV genotypes, the simple concordance rate was 90.8% (307/338) and the Kappa statistic value was 0.765, which shows substantial concordance. The positive concordance rate was 70.5% (74/105), which was the rate excluding women who had negative results in both tests. When limited to types 16 and 18, the simple concordance rate was 98.8% (334/338), and the Kappa statistical value was calculated to be 0.840, which showed almost perfect concordance. The positive concordance rate resulted in 81.8% (18/22). We conclude that the urine hrHPV-DNA test could substitute the cervical test in women with ASC-US.</p>
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/diagnostics11101895