CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation

Kitai, Yuichi; Ishiura, Marie; Saitoh, Kodai; Matsumoto, Naoki; Owashi, Kimiya; Yamada, Shunsuke; Muromoto, Ryuta; Kashiwakura, Jun-ichi; Oritani, Kenji; Matsuda, Tadashi

CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation

Kitai, Yuichi; Ishiura, Marie; Saitoh, Kodai et al.

International immunology, 2021, 33(5), 273-280

Permalink : https://hdl.handle.net/2115/83760

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アクセス権	open access
URI	https://hdl.handle.net/2115/83760
タイトル	CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation
著者	Kitai, Yuichi ; Ishiura, Marie ; Saitoh, Kodai ; Matsumoto, Naoki ; Owashi, Kimiya ; Yamada, Shunsuke ; Muromoto, Ryuta ; Kashiwakura, Jun-ichi ; Oritani, Kenji ; Matsuda, Tadashi
e-Rad_Researcher 90756165 著者名 Kitai, Yuichi
著者名 Ishiura, Marie
著者名 Saitoh, Kodai
著者名 Matsumoto, Naoki
著者名 Owashi, Kimiya
著者名 Yamada, Shunsuke
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
e-Rad_Researcher 90373290 著者名 Kashiwakura, Jun-ichi
e-Rad_Researcher 70324762 著者名 Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	integrin
	phagocytosis
	Rho-GEF
	small-G protein
	TSP-1
発行日	2021-01-06
出版者	Oxford University Press
収録物名	International immunology
巻(号)	33(5)
ページ	273-280
抄録	CD47, a 50 kDa transmembrane protein, facilitates integrin-mediated cell adhesion and inhibits cell engulfment by phagocytes. Since CD47 blocking promotes engulfment of cancer cells by macrophages, it is important to clarify the mechanism of CD47 signaling in order to develop treatments for diseases involving CD47-overexpressing cancer cells, including breast cancer and lymphoma. Here, we show that CD47 plays an essential role in T-cell lymphoma metastasis by up-regulating basal RhoA activity independent of its anti-phagocytic function. CD47 interacts with AKAP13, a RhoA-specific guanine nucleotide exchange factor (GEF), and facilitates AKAP13-mediated RhoA activation. Our study shows that CD47 has a novel function on the AKAP13-RhoA axis and suggests that CD47-AKAP13 interaction would be a novel target for T-cell lymphoma treatment.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in International immunology following peer review. The version of record International Immunology 2021 33(5):273–280 is available online at: https://doi.org/10.1093/intimm/dxab002.
PISSN	0953-8178
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/intimm/dxab002