Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

Ohno, Marumi; Sasaki, Michihito; Orba, Yasuko; Sekiya, Toshiki; Masum, Md. Abdul; Ichii, Osamu; Sawamura, Tatsuya; Kakino, Akemi; Suzuki, Yasuhiko; Kida, Hiroshi; Sawa, Hirofumi; Shingai, Masashi

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

Ohno, Marumi; Sasaki, Michihito; Orba, Yasuko et al.

Viruses-Basel, 2021, 13(11), 2137

Permalink : https://hdl.handle.net/2115/83782

このアイテムのアクセス数:509件（2026-01-15 05:01 集計）

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https://doi.org/10.3390/v13112137			3

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/83782
タイトル	Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2
著者	Ohno, Marumi ; Sasaki, Michihito ; Orba, Yasuko ; Sekiya, Toshiki ; Masum, Md. Abdul ; Ichii, Osamu ; Sawamura, Tatsuya ; Kakino, Akemi ; Suzuki, Yasuhiko ; Kida, Hiroshi ; Sawa, Hirofumi ; Shingai, Masashi
e-Rad_Researcher 50794202 著者名 Ohno, Marumi
e-Rad_Researcher 70609403 著者名 Sasaki, Michihito
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
著者名 Sekiya, Toshiki
著者名 Masum, Md. Abdul
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
著者名 Sawamura, Tatsuya
著者名 Kakino, Akemi
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
e-Rad_Researcher 80421981 著者名 Shingai, Masashi
言語	英語
キーワード	COVID-19
	animal model
	aged Syrian hamster
発行日	2021-11
出版者	MDPI
収録物名	Viruses-Basel
巻(号)	13(11)
ページ	2137
抄録	Systemic symptoms have often been observed in patients with coronavirus disease 2019 (COVID-19) in addition to pneumonia, however, the details are still unclear due to the lack of an appropriate animal model. In this study, we investigated and compared blood coagulation abnormalities and tissue damage between male Syrian hamsters of 9 (young) and over 36 (aged) weeks old after intranasal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite similar levels of viral replication and inflammatory responses in the lungs of both age groups, aged but not young hamsters showed significant prolongation of prothrombin time and prominent acute kidney damage. Moreover, aged hamsters demonstrated increased intravascular coagulation time-dependently in the lungs, suggesting that consumption of coagulation factors causes prothrombin time prolongation. Furthermore, proximal urinary tract damage and mesangial matrix expansion were observed in the kidneys of the aged hamsters at early and later disease stages, respectively. Given that the severity and mortality of COVID-19 are higher in elderly human patients, the effect of aging on pathogenesis needs to be understood and should be considered for the selection of animal models. We, thus, propose that the aged hamster is a good small animal model for COVID-19 research.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/v13112137