SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role

Mizutani, Yusuke; Omagari, Daisuke; Hayatsu, Manabu; Nameta, Masaaki; Komiyama, Kazuo; Mikami, Yoshikazu; Ushiki, Tatsuo

SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role

Mizutani, Yusuke; Omagari, Daisuke; Hayatsu, Manabu et al.

Cell Adhesion and Migration, 2020, 14(1), 195-203

Permalink : https://hdl.handle.net/2115/83788

このアイテムのアクセス数:405件（2026-01-13 11:38 集計）

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https://doi.org/10.1080/19336918.2020.1829264			3

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/83788
タイトル	SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role
著者	Mizutani, Yusuke ; Omagari, Daisuke ; Hayatsu, Manabu ; Nameta, Masaaki ; Komiyama, Kazuo ; Mikami, Yoshikazu ; Ushiki, Tatsuo
e-Rad_Researcher 40646238 著者名 Mizutani, Yusuke
e-Rad_Researcher 10608699 著者名 Omagari, Daisuke
著者名 Hayatsu, Manabu
著者名 Nameta, Masaaki
e-Rad_Researcher 00120452 著者名 Komiyama, Kazuo
e-Rad_Researcher 80434075 著者名 Mikami, Yoshikazu
e-Rad_Researcher 40184999 著者名 Ushiki, Tatsuo
言語	英語
キーワード	Carcinoma
	SLPI
	migration
	microscopic analysis
	Galectin4
発行日	2020-10-04
出版者	Taylor & Francis
収録物名	Cell Adhesion and Migration
巻(号)	14(1)
ページ	195-203
抄録	To elucidate the underlying mechanism of secretory leukocyte protease inhibitor (SLPI)-induced cell migration, we compared SLPI-deleted human gingival carcinoma Ca9-22 (Delta SLPI) cells and original (wild-type: wt) Ca9-22 cells using several microscopic imaging methods and gene expression analysis. Our results indicated reduced migration of Delta SLPI cells compared to wtCa9-22 cells. The lamellipodia/dorsal ruffles were smaller and moved slower in Delta SLPI cells compared to wtCa9-22 cells. Furthermore, well-developed intermediate filament bundles were observed at the desmosome junction of Delta SLPI cells. In addition,Galectin4was strongly expressed in Delta SLPI cells, and its forced expression suppressed migration of wtCa9-22 cells. Taken together, SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1933-6918
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1080/19336918.2020.1829264