Hair follicle stem cell progeny heal blisters while pausing skin development

Fujimura, Yu; Watanabe, Mika; Ohno, Kota; Kobayashi, Yasuaki; Takashima, Shota; Nakamura, Hideki; Kosumi, Hideyuki; Wang, Yunan; Mai, Yosuke; Lauria, Andrea; Proserpio, Valentina; Ujiie, Hideyuki; Iwata, Hiroaki; Nishie, Wataru; Nagayama, Masaharu; Oliviero, Salvatore; Donati, Giacomo; Shimizu, Hiroshi; Natsuga, Ken

Hair follicle stem cell progeny heal blisters while pausing skin development

Fujimura, Yu; Watanabe, Mika; Ohno, Kota et al.

EMBO Reports, 2021, 22(7), e50882

Permalink : https://hdl.handle.net/2115/83789

このアイテムのアクセス数:478件（2026-02-07 16:47 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83789
タイトル	Hair follicle stem cell progeny heal blisters while pausing skin development
著者	Fujimura, Yu ; Watanabe, Mika ; Ohno, Kota ; Kobayashi, Yasuaki ; Takashima, Shota ; Nakamura, Hideki ; Kosumi, Hideyuki ; Wang, Yunan ; Mai, Yosuke ; Lauria, Andrea ; Proserpio, Valentina ; Ujiie, Hideyuki ; Iwata, Hiroaki ; Nishie, Wataru ; Nagayama, Masaharu ; Oliviero, Salvatore ; Donati, Giacomo ; Shimizu, Hiroshi ; Natsuga, Ken
著者名 Fujimura, Yu
著者名 Watanabe, Mika
著者名 Ohno, Kota
著者名 Kobayashi, Yasuaki
著者名 Takashima, Shota
著者名 Nakamura, Hideki
著者名 Kosumi, Hideyuki
著者名 Wang, Yunan
著者名 Mai, Yosuke
著者名 Lauria, Andrea
著者名 Proserpio, Valentina
著者名 Ujiie, Hideyuki
著者名 Iwata, Hiroaki
著者名 Nishie, Wataru
著者名 Nagayama, Masaharu
著者名 Oliviero, Salvatore
著者名 Donati, Giacomo
著者名 Shimizu, Hiroshi
e-Rad_Researcher 70645457 著者名 Natsuga, Ken
言語	英語
キーワード	basement membrane zone
	epidermal stem cells
	epidermolysis bullosa
	Wnt signaling
発行日	2021-07-05
出版者	EMBO Press
収録物名	EMBO Reports
巻(号)	22(7)
ページ	e50882
抄録	Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it is not known whether this paradigm applies to growing tissue. Here, by employing blisters, we show that epidermal wounds heal at the expense of skin development. The regenerated epidermis suppresses the expression of tissue morphogenesis genes accompanied by delayed hair follicle (HF) growth. Lineage tracing experiments, cell proliferation dynamics, and mathematical modeling reveal that the progeny of HF junctional zone stem cells, which undergo a morphological transformation, repair the blisters while not promoting HF development. In contrast, the contribution of interfollicular stem cell progeny to blister healing is small. These findings demonstrate that HF development can be sacrificed for the sake of epidermal wound regeneration. Our study elucidates the key cellular mechanism of wound healing in skin blistering diseases.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1469-221X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.15252/embr.202050882