Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

Shinkai, Akihiro; Shinmei, Yasuhiro; Hirooka, Kiriko; Tagawa, Yoshiaki; Nakamura, Kayoko; Chin, Shinki; Ishida, Susumu

Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

Shinkai, Akihiro; Shinmei, Yasuhiro; Hirooka, Kiriko et al.

Mitochondrion, 2021, 56, 47-51

Permalink : https://hdl.handle.net/2115/83790

このアイテムのアクセス数:424件（2026-02-18 20:42 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/83790
タイトル	Optical coherence tomography as a possible tool to monitor and predict disease progression in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
著者	Shinkai, Akihiro ; Shinmei, Yasuhiro ; Hirooka, Kiriko ; Tagawa, Yoshiaki ; Nakamura, Kayoko ; Chin, Shinki ; Ishida, Susumu
著者名 Shinkai, Akihiro
e-Rad_Researcher 00374398 著者名 Shinmei, Yasuhiro
著者名 Hirooka, Kiriko
e-Rad_Researcher 50632494 著者名 Tagawa, Yoshiaki
著者名 Nakamura, Kayoko
e-Rad_Researcher 90236844 著者名 Chin, Shinki
e-Rad_Researcher 10245558 著者名 Ishida, Susumu
言語	英語
キーワード	Mitochondrial myopathy
	Encephalopathy
	Lactic acidosis and stroke-like episodes
	Optical coherence tomography
	Leber hereditary optic neuropathy
	Ganglion cell complex
	Homonymous hemianopia
発行日	2021-01
出版者	Elsevier
収録物名	Mitochondrion
巻(号)	56
ページ	47-51
抄録	Optical coherence tomography (OCT) is an imaging technique used to obtain three-dimensional information on the retina. In this article, we evaluated the structural neuro-retinal abnormalities, especially the thickness in the ganglion cell complex (GCC), in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The GCC thickness in MELAS patients was significantly thinner than that in normal controls even when they had no history of transient homonymous hemianopia. There was a negative correlation between GCC thickness and disease duration. In conclusion, OCT may be an effective tool to monitor and predict disease progression in MELAS patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1567-7249
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.mito.2020.11.003