Reliability of an ultrasonographical scoring system for diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease in patients with hematopoietic stem cell transplantation

Iwai, Takahito; Nishida, Mutsumi; Sugita, Junichi; Kudo, Yusuke; Takasugi, Rika; Yokota, Isao; Takagi, Ryo; Shibuya, Hitoshi; Takahashi, Shuichiro; Teshima, Takanori

Reliability of an ultrasonographical scoring system for diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease in patients with hematopoietic stem cell transplantation

Iwai, Takahito; Nishida, Mutsumi; Sugita, Junichi et al.

Journal of medical ultrasonics, 2021, 48(1), 45-52

Permalink : https://hdl.handle.net/2115/83793

このアイテムのアクセス数:734件（2026-03-16 18:54 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/83793
タイトル	Reliability of an ultrasonographical scoring system for diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease in patients with hematopoietic stem cell transplantation
著者	Iwai, Takahito ; Nishida, Mutsumi ; Sugita, Junichi ; Kudo, Yusuke ; Takasugi, Rika ; Yokota, Isao ; Takagi, Ryo ; Shibuya, Hitoshi ; Takahashi, Shuichiro ; Teshima, Takanori
著者名 Iwai, Takahito
e-Rad_Researcher 90404722 著者名 Nishida, Mutsumi
著者名 Sugita, Junichi
著者名 Kudo, Yusuke
著者名 Takasugi, Rika
e-Rad_Researcher 20761414 著者名 Yokota, Isao
著者名 Takagi, Ryo
著者名 Shibuya, Hitoshi
e-Rad_Researcher 90828295 著者名 Takahashi, Shuichiro
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	Sinusoidal obstruction syndrome
	Hepatic veno-occlusive disease
	Hematopoietic stem cell transplantation
	Operator reliability
	Ultrasonography
発行日	2021-01
出版者	Springer
収録物名	Journal of medical ultrasonics
巻(号)	48(1)
ページ	45-52
抄録	Purpose Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a fatal complication after hematopoietic stem cell transplantation. We previously reported the usefulness of an ultrasonographical (US) scoring system, the Hokkaido US-based scoring system consisting of ten parameters (HokUS-10): (1) hepatomegaly in the left lobe and (2) right lobe, (3) dilatation of the main portal vein (PV), (4) hepatofugal flow in the main PV, (5) decreased velocity of the PV, (6) dilatation of the para-umbilical vein (PUV), (7) appearance of blood flow signal in the PUV, (8) gallbladder (GB) wall thickening, (9) ascites, and (10) increased resistive index of the hepatic artery, for the diagnosis of SOS/VOD. However, the reliability of this system among operators remains elusive. Therefore, we prospectively evaluated the reliability of HokUS-10. Methods Twenty-four healthy volunteers and 40 patients with liver dysfunction were enrolled. Inter- and intra-operator reliabilities were analyzed using three sonographers. Results The median concordance rate of HokUS-10 among three sonographers and intra-operator in 24 volunteers was 92% (95% CI: 73-98%) and 98% (95% CI: 92-100%), respectively. In all 64 cases, in terms of the reliability between two sonographers for three representative US parameters (amount of ascites, GB wall thickening, and appearance of PUV blood flow signal), the median concordance rate was more than 98% (95% CI: 86-106%). Conclusion The inter- and intra-reliabilities of HokUS-10 were excellent. Thus, US might be a reliable tool for SOS/VOD diagnosis.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Journal of medical ultrasonics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10396-020-01071-1
PISSN	1346-4523
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10396-020-01071-1