Insights into phosphatase-activated chemical defense in a marine sponge holobiont

Jomori, Takahiro; Matsuda, Kenichi; Egami, Yoko; Abe, Ikuro; Takai, Akira; Wakimoto, Toshiyuki

Insights into phosphatase-activated chemical defense in a marine sponge holobiont

Jomori, Takahiro; Matsuda, Kenichi; Egami, Yoko et al.

RSC Chemical Biology, 2021, 2(6), 1600-1607

Permalink : https://hdl.handle.net/2115/83835

このアイテムのアクセス数:542件（2026-03-11 22:39 集計）

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https://doi.org/10.1039/d1cb00163a			7

論文情報

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/83835
タイトル	Insights into phosphatase-activated chemical defense in a marine sponge holobiont
著者	Jomori, Takahiro ; Matsuda, Kenichi ; Egami, Yoko ; Abe, Ikuro ; Takai, Akira ; Wakimoto, Toshiyuki
著者名 Jomori, Takahiro
e-Rad_Researcher 50812301 著者名 Matsuda, Kenichi
e-Rad_Researcher 50758612 著者名 Egami, Yoko
e-Rad_Researcher 40305496 著者名 Abe, Ikuro
e-Rad_Researcher 50126869 著者名 Takai, Akira
e-Rad_Researcher 70363900 著者名 Wakimoto, Toshiyuki
言語	英語
発行日	2021-10-06
出版者	Royal Society of Chemistry
収録物名	RSC Chemical Biology
巻(号)	2(6)
ページ	1600-1607
抄録	Marine sponges often contain potent cytotoxic compounds, which in turn evokes the principle question of how marine sponges avoid self-toxicity. In a marine sponge Discodermia calyx, the highly toxic calyculin A is detoxified by the phosphorylation, which is catalyzed by the phosphotransferase CalQ of a producer symbiont, "Candidatus Entotheonella" sp. Here we show the activating mechanism to dephosphorylate the stored phosphocalyculin A protoxin. The phosphatase specific to phosphocalyculin A is CalL, which is also encoded in the calyculin biosynthetic gene cluster. CalL represents a new clade and unprecedently coordinates the heteronuclear metals Cu and Zn. CalL is localized in the periplasmic space of the sponge symbiont, where it is ready for the on-demand production of calyculin A in response to sponge tissue disruption.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2633-0679
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1039/d1cb00163a