A treatment planning study of urethra-sparing intensity-modulated proton therapy for localized prostate cancer

Yoshimura, Takaaki; Nishioka, Kentaro; Hashimoto, Takayuki; Seki, Kazuya; Kogame, Shouki; Tanaka, Sodai; Kanehira, Takahiro; Tamura, Masaya; Takao, Seishin; Matsuura, Taeko; Kobashi, Keiji; Kato, Fumi; Aoyama, Hidefumi; Shimizu, Shinichi

A treatment planning study of urethra-sparing intensity-modulated proton therapy for localized prostate cancer

Yoshimura, Takaaki; Nishioka, Kentaro; Hashimoto, Takayuki et al.

Physics and Imaging in Radiation Oncology, 2021, 20, 23-29

Permalink : https://hdl.handle.net/2115/83937

このアイテムのアクセス数:393件（2026-01-18 17:16 集計）

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https://doi.org/10.1016/j.phro.2021.09.006			1

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/83937
タイトル	A treatment planning study of urethra-sparing intensity-modulated proton therapy for localized prostate cancer
著者	Yoshimura, Takaaki ; Nishioka, Kentaro ; Hashimoto, Takayuki ; Seki, Kazuya ; Kogame, Shouki ; Tanaka, Sodai ; Kanehira, Takahiro ; Tamura, Masaya ; Takao, Seishin ; Matsuura, Taeko ; Kobashi, Keiji ; Kato, Fumi ; Aoyama, Hidefumi ; Shimizu, Shinichi
e-Rad_Researcher 70807742 著者名 Yoshimura, Takaaki
e-Rad_Researcher 80463743 著者名 Nishioka, Kentaro
e-Rad_Researcher 60400678 著者名 Hashimoto, Takayuki
著者名 Seki, Kazuya
著者名 Kogame, Shouki
e-Rad_Researcher 00826092 著者名 Tanaka, Sodai
著者名 Kanehira, Takahiro
e-Rad_Researcher 40504775 著者名 Tamura, Masaya
e-Rad_Researcher 10614216 著者名 Takao, Seishin
e-Rad_Researcher 90590266 著者名 Matsuura, Taeko
著者名 Kobashi, Keiji
e-Rad_Researcher 80399865 著者名 Kato, Fumi
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
言語	英語
キーワード	Urethra-sparing radiotherapy
	Prostate cancer
	Intensity-modulated proton therapy
	Tumor control probability
	Normal tissue complication probability
発行日	2021-10
出版者	Elsevier
収録物名	Physics and Imaging in Radiation Oncology
巻(号)	20
ページ	23-29
抄録	Background and Purpose: Urethra-sparing radiation therapy for localized prostate cancer can reduce the risk of radiation-induced genitourinary toxicity by intentionally underdosing the periurethral transitional zone. We aimed to compare the clinical impact of a urethra-sparing intensity-modulated proton therapy (US-IMPT) plan with that of conventional clinical plans without urethral dose reduction. Materials and Methods: This study included 13 patients who had undergone proton beam therapy. The prescribed dose was 63 GyE in 21 fractions for 99% of the clinical target volume. To compare the clinical impact of the US-IMPT plan with that of the conventional clinical plan, tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated with a generalized equivalent uniform dose-based Lyman-Kutcher model using dose volume histograms. The endpoints of these model parameters for the rectum, bladder, and urethra were fistula, contraction, and urethral stricture, respectively. Results: The mean NTCP value for the urethra in US-IMPT was significantly lower than that in the conventional clinical plan (0.6% vs. 1.2%, p < 0.05). There were no statistically significant differences between the conventional and US-IMPT plans regarding the mean minimum dose for the urethra with a 3-mm margin, TCP value, and NTCP value for the rectum and bladder. Additionally, the target dose coverage of all plans in the robustness analysis was within the clinically acceptable range. Conclusions: Compared with the conventional clinically applied plans, US-IMPT plans have potential clinical advantages and may reduce the risk of genitourinary toxicities, while maintaining the same TCP and NTCP in the rectum and bladder.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.phro.2021.09.006