Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

Muthusinghe, Devinda S.; Shimizu, Kenta; Lokupathirage, Sithumini M. W. et al.

Viruses-Basel, 2021, 13(10), 1984

Permalink : https://hdl.handle.net/2115/83963

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URI
https://hdl.handle.net/2115/83963
タイトル
Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka
著者
Muthusinghe, Devinda S. ; Shimizu, Kenta ; Lokupathirage, Sithumini M. W. ; Wei, Zhouoxing ; Sarathkumara, Yomani D. ; Fonseka, G. R. Amanda ; Senarathne, Pavani ; Koizumi, Nobuo ; Kawakami, Tomonori ; Koizumi, Akio ; Wickramasinghe, Chaminda ; Ebihara, Hideki ; Matsuno, Keita ; Tsuda, Yoshimi ; Arikawa, Jiro ; Gamage, Chandika D. ; Yoshimatsu, Kumiko
著者名
Muthusinghe, Devinda S.
著者名
Shimizu, Kenta
著者名
Lokupathirage, Sithumini M. W.
著者名
Wei, Zhouoxing
著者名
Sarathkumara, Yomani D.
著者名
Fonseka, G. R. Amanda
著者名
Senarathne, Pavani
著者名
Koizumi, Nobuo
著者名
Kawakami, Tomonori
著者名
Koizumi, Akio
著者名
Wickramasinghe, Chaminda
著者名
Ebihara, Hideki
著者名
Matsuno, Keita
著者名
Tsuda, Yoshimi
著者名
Arikawa, Jiro
著者名
Gamage, Chandika D.
e-Rad_Researcher
90220722
著者名
Yoshimatsu, Kumiko
言語
英語
キーワード
hantavirus
Mus booduga
Thailand orthohantavirus
Anjozorobe hantavirus
発行日
2021-10
出版者
MDPI
収録物名
Viruses-Basel
巻(号)
13(10)
ページ
1984
抄録
We reported the genetic evidence of circulating hantaviruses from small mammals captured in a chronic kidney disease of unknown etiology (CKDu) hotspot area of Sri Lanka. The high seroprevalence of anti-hantavirus antibodies against Thailand orthohantavirus (THAIV) has been reported among CKDu patients and rodents in Sri Lankan CKDu hotspots. We captured 116 small mammals from CKDu endemic regions in the Polonnaruwa District of Sri Lanka. Seven animals (five out of 11 Mus booduga and two out of 99 Rattus rattus) were PCR-positive for the hantavirus. A rat-borne sequence was grouped with a THAIV-like Anjozorobe virus. In contrast, Mus-borne sequences belonged to the THAIV lineage, suggesting a novel orthohantavirus species according to the phylogenetic analyses and whole-genome comparisons. Our genetic evidence indicates the presence of two THAIV-related viruses circulating in this CKDu endemic area, suggesting a basis for further investigations to identify the infectious virus in patients with CKDu and the CKDu induction mechanism of these viruses.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/v13101984