Delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes polymorphisms in children residing in an abandoned lead-zinc mine area in Kabwe, Zambia

Yohannes, Yared B.; Nakayama, Shouta M. M.; Yabe, John; Toyomaki, Haruya; Kataba, Andrew; Nakata, Hokuto; Muzandu, Kaampwe; Ikenaka, Yoshinori; Choongo, Kennedy; Ishizuka, Mayumi

Delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes polymorphisms in children residing in an abandoned lead-zinc mine area in Kabwe, Zambia

Yohannes, Yared B.; Nakayama, Shouta M. M.; Yabe, John et al.

Meta gene, 2021, 27, 100838

Permalink : https://hdl.handle.net/2115/84016

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アクセス権	open access
URI	https://hdl.handle.net/2115/84016
タイトル	Delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes polymorphisms in children residing in an abandoned lead-zinc mine area in Kabwe, Zambia
著者	Yohannes, Yared B. ; Nakayama, Shouta M. M. ; Yabe, John ; Toyomaki, Haruya ; Kataba, Andrew ; Nakata, Hokuto ; Muzandu, Kaampwe ; Ikenaka, Yoshinori ; Choongo, Kennedy ; Ishizuka, Mayumi
著者名 Yohannes, Yared B.
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Yabe, John
著者名 Toyomaki, Haruya
著者名 Kataba, Andrew
e-Rad_Researcher 60815273 著者名 Nakata, Hokuto
著者名 Muzandu, Kaampwe
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
著者名 Choongo, Kennedy
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Lead
	Gene polymorphism
	ALAD
	VDR
	Children
発行日	2021-02
出版者	Elsevier
収録物名	Meta gene
巻(号)	27
ページ	100838
抄録	Lead is a ubiquitous environmental pollutant that poses serious health problems to humans, especially to children. However, genetic variability in individuals varies their susceptibility to lead poisoning. One possible factor is genetic polymorphism. Thus, this study aimed to investigate the association between blood lead level (BLL), and polymorphisms in the delta-aminolevulinic acid dehydratase (ALAD) MspI (rs1800435) and vitamin D receptor (VDR) FokI (rs19735810), BsmI (rs15444410), ApaI (rs7975232) and TaqI (rs731236) genes in children exposed to lead. A total of 140 children (aged 2-10 years) were recruited in areas living closer to and far away from an abandoned lead-zinc mine in Kabwe, Zambia. Blood samples were collected from each child for BLLs and polymorphisms analysis. All children were homozygous for the ALAD 1 allele, indicating there might be bioavailable lead in the children's blood which can transfer to the soft tissues and the brain. The distribution of the VDR gene polymorphisms showed major alleles prevalence's of 81%, 80%, 68%, and 75% for FokI, BsmI, ApaI, and TaqI polymorphisms, respectively. The aa genotype of VDR ApaI showed significantly higher BLL compared to other genotypes of the VDRs polymorphism. The TaqI - TT genotype was associated with an increase of lead exposure risk in female children (OR = 2.06; 95% CI:1.04-4.06, p = 0.03). The haplotype analysis showed 10 haplotypes with a frequency above 1%, and the FbAt haplotype showed a protective role against lead toxicity. In conclusion, the children, especially female children, which exposed to lead mainly from the abandoned lead-zinc mine might be at a higher risk of developing lead poisoning. Further, larger scale sample sizes are needed to corroborate the role of ALAD and VDR genetic variants on the implications of lead toxicity in the general population, particularly in children.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© <2021>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	2214-5400
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.mgene.2020.100838