Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis

Koyanagawa, Kazuhiro; Naya, Masanao; Aikawa, Tadao; Manabe, Osamu; Kuzume, Masato; Ohira, Hiroshi; Tsujino, Ichizo; Tamaki, Nagara; Anzai, Toshihisa

Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis

Koyanagawa, Kazuhiro; Naya, Masanao; Aikawa, Tadao et al.

Journal of nuclear cardiology, 2021, 28(1), 128-136

Permalink : https://hdl.handle.net/2115/84039

このアイテムのアクセス数:426件（2026-01-17 15:49 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/84039
タイトル	Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis
著者	Koyanagawa, Kazuhiro ; Naya, Masanao ; Aikawa, Tadao ; Manabe, Osamu ; Kuzume, Masato ; Ohira, Hiroshi ; Tsujino, Ichizo ; Tamaki, Nagara ; Anzai, Toshihisa
著者名 Koyanagawa, Kazuhiro
e-Rad_Researcher 20455637 著者名 Naya, Masanao
著者名 Aikawa, Tadao
著者名 Manabe, Osamu
著者名 Kuzume, Masato
著者名 Ohira, Hiroshi
著者名 Tsujino, Ichizo
著者名 Tamaki, Nagara
e-Rad_Researcher 60232089 著者名 Anzai, Toshihisa
言語	英語
キーワード	Cardiac sarcoidosis
	Electrocardiography-gated single-photon emission computed tomography
	F-18
	fluorideoxyglucose positron emission tomography-computed tomography
	Phase analysis
	Major adverse cardiac events
発行日	2021-02
出版者	Springer
収録物名	Journal of nuclear cardiology
巻(号)	28(1)
ページ	128-136
抄録	Background We aimed to determine the correlation between phase analysis, reflecting the heterogeneity of perfusion defects, and the dyssynchrony of the left ventricle wall motion, and adverse cardiac events in cardiac sarcoidosis (CS) patients. Methods Fifty-seven consecutive patients with diagnosed CS (64 [IQR 55-71] years old, 14 males), who underwent F-18-FDG PET/CT and ECG-gated SPECT, were studied. FDG PET was analysed to measure cardiac metabolic volume (CMV), and total lesion glycolysis (TLG). The SPECT findings, such as LVEF, Summed Rest Score (SRS), bandwidth (BW) were evaluated. Results The median of BW was 56 degrees (IQR 40-95). BW showed a strong inverse correlation with LVEF (r = - 0.60, P < 0.0001), and positive correlation with SRS (r = 0.82, P < 0.0001). However, there were no significant correlations between BW and CMV or TLG. The Kaplan-Meier curves revealed a significantly higher rate of MACE in the high BW group (BW > 56 degrees) than the low BW group (BW <= 56 degrees) (15.1%/years vs. 4.4%/years, P = 0.025). In multivariable analysis, BW was a significant independent predictor of MACE (P = 0.015). Conclusion Phase analysis on gated SPECT was a significant and independent predictor of MACE in patients with CS.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Journal of nuclear cardiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12350-019-01660-9
PISSN	1071-3581
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12350-019-01660-9