The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma

Nakamaru, Yuji; Suzuki, Masanobu; Kano, Satoshi; Mizumachi, Takatsugu; Tsushima, Nayuta; Suzuki, Takayoshi; Honma, Aya; Nakazono, Akira; Kimura, Shogo; Onimaru, Rikiya; Yasuda, Koichi; Shirato, Hiroki; Homma, Akihiro

The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma

Nakamaru, Yuji; Suzuki, Masanobu; Kano, Satoshi et al.

Auris nasus larynx, 2021, 48(1), 131-137

Permalink : https://hdl.handle.net/2115/84040

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アクセス権	open access
URI	https://hdl.handle.net/2115/84040
タイトル	The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma
著者	Nakamaru, Yuji ; Suzuki, Masanobu ; Kano, Satoshi ; Mizumachi, Takatsugu ; Tsushima, Nayuta ; Suzuki, Takayoshi ; Honma, Aya ; Nakazono, Akira ; Kimura, Shogo ; Onimaru, Rikiya ; Yasuda, Koichi ; Shirato, Hiroki ; Homma, Akihiro
e-Rad_Researcher 20344509 著者名 Nakamaru, Yuji
e-Rad_Researcher 70455658 著者名 Suzuki, Masanobu
著者名 Kano, Satoshi
著者名 Mizumachi, Takatsugu
著者名 Tsushima, Nayuta
著者名 Suzuki, Takayoshi
著者名 Honma, Aya
著者名 Nakazono, Akira
著者名 Kimura, Shogo
著者名 Onimaru, Rikiya
著者名 Yasuda, Koichi
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
言語	英語
キーワード	Squamous cell carcinoma
	Endoscopic sinus surgery
	Nasal cavity
	Paranasal sinus
	Surgical margin
発行日	2021-02-01
出版者	Elsevier
収録物名	Auris nasus larynx
巻(号)	48(1)
ページ	131-137
抄録	Objective: Despite of rapid advances in endoscopic surgery, the gold standard for sinonasal squamous cell carcinoma (SNSCC) surgery has remained the open approach with en-block resection due to the aggressive nature of SNSCC, including frequent recurrence and high mortality rate. For that reason, few studies have focused on SNSCC treated by endoscopic surgery alone. The objective of this study was to evaluate the usefulness of endoscopic surgery for patients with SNSCC. Methods: A retrospective analysis was performed for 15 consecutive SNSCC patients who underwent endoscopic surgery without an open approach. We carefully selected patients whose tumor attachment sites could be fully visualized and completely resected through an endonasal approach. Results: Of the fifteen patients, 4 patients (27%) were diagnosed with T1, 7 (47%) with T2, 4 (27%) with T3, and no patients with T4a or T4b disease. Four of the 15 (27%) patients showed positive surgical margins. The 5-yr overall survival, disease-specific survival, and local control rate was 72.4%, 79.6%, and 92.9%, respectively. The 5-yr disease-specific survival for T1, T2, and T3 disease was 100% and 75% and 75%, respectively. Patients with negative surgical margins had a better disease-specific survival rate than did those with positive surgical margins (p = 0.0253). Conclusion: Endoscopic surgery for patients with SNSCC appears to afford an effective method in selected cases. The achievement of negative surgical margins with a good view of the tumor attachment site was considered to be critical to the management of SNSCC. (c) 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0385-8146
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.anl.2020.06.014