Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens

Fujisawa, Sotaro; Murata, Shiro; Isezaki, Masayoshi; Ariizumi, Takuma; Sato, Takumi; Oishi, Eiji; Taneno, Akira; Maekawa, Naoya; Okagawa, Tomohiro; Ichii, Osamu; Konnai, Satoru; Ohashi, Kazuhiko

Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens

Fujisawa, Sotaro; Murata, Shiro; Isezaki, Masayoshi et al.

Vaccines, 2021, 9(12), 1472

Permalink : https://hdl.handle.net/2115/84052

このアイテムのアクセス数:463件（2026-02-12 22:00 集計）

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https://doi.org/10.3390/vaccines9121472

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84052
タイトル	Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens
著者	Fujisawa, Sotaro ; Murata, Shiro ; Isezaki, Masayoshi ; Ariizumi, Takuma ; Sato, Takumi ; Oishi, Eiji ; Taneno, Akira ; Maekawa, Naoya ; Okagawa, Tomohiro ; Ichii, Osamu ; Konnai, Satoru ; Ohashi, Kazuhiko
著者名 Fujisawa, Sotaro
e-Rad_Researcher 10579163 著者名 Murata, Shiro
著者名 Isezaki, Masayoshi
著者名 Ariizumi, Takuma
著者名 Sato, Takumi
著者名 Oishi, Eiji
著者名 Taneno, Akira
e-Rad_Researcher 70829035 著者名 Maekawa, Naoya
e-Rad_Researcher 80829036 著者名 Okagawa, Tomohiro
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
e-Rad_Researcher 40396304 著者名 Konnai, Satoru
e-Rad_Researcher 90250498 著者名 Ohashi, Kazuhiko
言語	英語
キーワード	Dermanyssus gallinae
	poultry red mite
	cystatin
	vaccine
	cocktail vaccine
発行日	2021-12
出版者	MDPI
収録物名	Vaccines
巻(号)	9(12)
ページ	1472
抄録	Poultry red mite (PRM; Dermanyssus gallinae) is a hazardous, blood-sucking ectoparasite of birds that constitutes a threat to poultry farming worldwide. Acaricides, commonly used in poultry farms to prevent PRMs, are not effective because of the rapid emergence of acaricide-resistant PRMs. However, vaccination may be a promising strategy to control PRM. We identified a novel cystatin-like molecule in PRMs: Dg-Cys. Dg-Cys mRNA expression was detected in the midgut and ovaries, in all stages of life. The PRM nymphs that were artificially fed with the plasma from chickens that were immunized with Dg-Cys in vitro had a significantly reduced reproductive capacity and survival rate. Moreover, combination of Dg-Cys with other antigen candidates, like copper transporter 1 or adipocyte plasma membrane-associated protein, enhanced vaccine efficacies. vaccination and its application as an antigen for cocktail vaccines could be an effective strategy to reduce the damage caused by PRMs in poultry farming.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/vaccines9121472