Identification of pulvomycin as an inhibitor of the futalosine pathway

Ogasawara, Yasushi; Umetsu, Shuhei; Inahashi, Yuki et al.

Journal of antibiotics, 2021, 74, 825-829

Permalink : https://hdl.handle.net/2115/84174

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manuscript-pulvomycin for HUSCAP	pdf	928 KB	362

アクセス権	open access
URI	https://hdl.handle.net/2115/84174
タイトル	Identification of pulvomycin as an inhibitor of the futalosine pathway
著者	Ogasawara, Yasushi ; Umetsu, Shuhei ; Inahashi, Yuki ; Nonaka, Kenichi ; Dairi, Tohru
e-Rad_Researcher 20732986 著者名 Ogasawara, Yasushi
著者名 Umetsu, Shuhei
著者名 Inahashi, Yuki
著者名 Nonaka, Kenichi
e-Rad_Researcher 70264679 著者名 Dairi, Tohru
言語	英語
発行日	2021-08-20
出版者	Springer Nature
収録物名	Journal of antibiotics
巻(号)	74
ページ	825-829
抄録	Menaquinone is an essential cofactor in the electron-transfer pathway for bacteria. Menaquinone is biosynthesized from chorismate using either the well-known canonical pathway established by pioneering studies in model microorganisms or the futalosine pathway, which we discovered in Streptomyces. Because Helicobacter pylori, which causes stomach cancer, uses the futalosine pathway and most beneficial intestinal bacteria including lactobacilli use the canonical pathway, the futalosine pathway will be a great target to develop antibiotics specific for H. pylori. Here, we searched for such compounds from metabolites produced by actinomycetes and identified pulvomycin from culture broth of Streptomyces sp. K18-0194 as a specific inhibitor of the futalosine pathway.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0021-8820
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/s41429-021-00465-8