PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity

Oziri, Onyinyechukwu Justina; Wang, Yubo; Watanabe, Tomohisa et al.

Nanoscale advances, 2022, 2022(4), 532-545

Permalink : https://hdl.handle.net/2115/84175

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https://doi.org/10.1039/d1na00720c     1

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アクセス権
metadata only access
URI
https://hdl.handle.net/2115/84175
タイトル
PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity
著者
Oziri, Onyinyechukwu Justina ; Wang, Yubo ; Watanabe, Tomohisa ; Uno, Shuya ; Maeki, Masatoshi ; Tokeshi, Manabu ; Isono, Takuya ; Tajima, Kenji ; Satoh, Toshifumi ; Sato, Shin-ichiro ; Miura, Yutaka ; Yamamoto, Takuya
著者名
Oziri, Onyinyechukwu Justina
著者名
Wang, Yubo
著者名
Watanabe, Tomohisa
著者名
Uno, Shuya
著者名
Maeki, Masatoshi
e-Rad_Researcher
60311437
著者名
Tokeshi, Manabu
著者名
Isono, Takuya
e-Rad_Researcher
00271643
著者名
Tajima, Kenji
e-Rad_Researcher
80291235
著者名
Satoh, Toshifumi
e-Rad_Researcher
10262601
著者名
Sato, Shin-ichiro
著者名
Miura, Yutaka
e-Rad_Researcher
30525986
著者名
Yamamoto, Takuya
言語
英語
発行日
2022-02-21
出版者
Royal Society of Chemistry
収録物名
Nanoscale advances
巻(号)
2022(4)
ページ
532-545
抄録
Silver nanoparticles (AgNPs) are practically valuable in biological applications. However, no steady PEGylation has been established, which is essential for internal use in humans or animals. In this study, cyclic PEG (c-PEG) without any chemical inhomogeneity is physisorbed onto AgNPs to successfully PEGylate and drastically enhance the dispersion stability against physiological conditions, white light, and high temperature. In contrast, linear HO-PEG-OH and MeO-PEG-OMe do not confer stability to AgNPs, and HS-PEG-OMe, which is often used for gold nanoparticles, sulfidates the surface to considerably degrade the properties. TEM shows an essentially intact nanostructure of c-PEG-physisorbed AgNPs even after heating at 95 degrees C, while complete disturbance is observed for other AgNPs. Molecular weight- and concentration-dependent stabilization by c-PEG is investigated, and DLS and zeta-potential measurements prove the formation of a c-PEG layer on the surface of AgNPs. Furthermore, c-PEG-physisorbed AgNPs exhibit persistent antimicrobial activity and cytotoxicity.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
2516-0230
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1039/d1na00720c