Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI

Kusumi, Ichiro; Masui, Takuya; Kakiuchi, Chihiro; Suzuki, Katsuji; Akimoto, Tatsuyuki; Hashimoto, Ryota; Kunugi, Hiroshi; Kato, Tadafumi; Koyama, Tsukasa

Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI

Kusumi, Ichiro; Masui, Takuya; Kakiuchi, Chihiro et al.

Neuroscience Letters, 2005, 391(1-2), 7-10

Permalink : https://hdl.handle.net/2115/8420

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アクセス権	open access
URI	https://hdl.handle.net/2115/8420
タイトル	Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
著者	Kusumi, Ichiro ; Masui, Takuya ; Kakiuchi, Chihiro ; Suzuki, Katsuji ; Akimoto, Tatsuyuki ; Hashimoto, Ryota ; Kunugi, Hiroshi ; Kato, Tadafumi ; Koyama, Tsukasa
e-Rad_Researcher 30250426 著者名 Kusumi, Ichiro
著者名 Masui, Takuya
著者名 Kakiuchi, Chihiro
著者名 Suzuki, Katsuji
著者名 Akimoto, Tatsuyuki
著者名 Hashimoto, Ryota
著者名 Kunugi, Hiroshi
著者名 Kato, Tadafumi
著者名 Koyama, Tsukasa
言語	英語
キーワード	XBP1
	Polymorphism
	Personality
	TCI
	NEO-FFI
発行日	2005-12-31
出版者	Elsevier
収録物名	Neuroscience Letters
巻(号)	391(1-2)
ページ	7-10
抄録	There have been several researches on the role of personality in the pathophysiology of bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Therefore, in this study, we examined the relationship between the XBP1 gene polymorphism and the personality traits assessed by two self-rating scales, a shortened version of Temperament and Character Inventory (TCI) and NEO-Five Factor Inventory (NEO-FFI) in healthy subjects. The present results suggested that the XBP1 gene polymorphism was associated with the NEO-FFI score of neuroticism in female subjects. However, no significant differences in the other personality scale scores of both assessments were observed among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0304-3940
関連情報	PMID 16154272
関連情報	URI http://www.sciencedirect.com/science/journal/03043940
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.neulet.2005.08.023