Morbidity and mortality in antiphospholipid syndrome based on cluster Analysis : a 10-year longitudinal cohort study

Ogata, Yusuke; Fujieda, Yuichiro; Sugawara, Masanari; Sato, Taiki; Ohnishi, Naoki; Kono, Michihito; Kato, Masaru; Oku, Kenji; Amengual, Olga; Atsumi, Tatsuya

Morbidity and mortality in antiphospholipid syndrome based on cluster Analysis : a 10-year longitudinal cohort study

Ogata, Yusuke; Fujieda, Yuichiro; Sugawara, Masanari et al.

Rheumatology, 2021, 60(3), 1331-1337

Permalink : https://hdl.handle.net/2115/84220

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アクセス権	open access
URI	https://hdl.handle.net/2115/84220
タイトル	Morbidity and mortality in antiphospholipid syndrome based on cluster Analysis : a 10-year longitudinal cohort study
著者	Ogata, Yusuke ; Fujieda, Yuichiro ; Sugawara, Masanari ; Sato, Taiki ; Ohnishi, Naoki ; Kono, Michihito ; Kato, Masaru ; Oku, Kenji ; Amengual, Olga ; Atsumi, Tatsuya
著者名 Ogata, Yusuke
e-Rad_Researcher 70790872 著者名 Fujieda, Yuichiro
著者名 Sugawara, Masanari
著者名 Sato, Taiki
著者名 Ohnishi, Naoki
e-Rad_Researcher 00835192 著者名 Kono, Michihito
著者名 Kato, Masaru
e-Rad_Researcher 70544295 著者名 Oku, Kenji
著者名 Amengual, Olga
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	antiphospholipid syndrome (APS)
	morbidity
	mortality
	cardiovascular risks
	history of arterial thrombosis
	cluster analysis
発行日	2021-03
出版者	Oxford University Press
収録物名	Rheumatology
巻(号)	60(3)
ページ	1331-1337
抄録	Objective. Using cluster analysis, to identify the subgroup of patients with APS with the poorest prognosis and clarify the characteristics of that subgroup. Methods. This is a longitudinal retrospective cohort study of APS patients. Using clinical data and the profile of aPL, cluster analysis was performed to classify the patients into subgroups. Events were defined as thrombosis, severe bleeding, and mortality. Results. A total of 168 patients with APS were included. Cluster analysis classified the patients into three subgroups; Cluster A (n = 61): secondary APS, Cluster B (n = 56): accumulation of cardiovascular risks and arterial thrombosis, Cluster C (n = 61): triple positivity of aPL and venous thrombosis. Cluster B showed significantly higher frequency of the events and higher mortality compared with the other clusters (P = 0.0112 for B vs A and P = 0.0471 for B vs C). Conclusion. Using cluster analysis, we clarified the characteristics of the APS patients with the poorest prognosis. Risk factors for cardiovascular disease may further increase events in patients with APS.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record Yusuke Ogata, Yuichiro Fujieda, Masanari Sugawara, Taiki Sato, Naoki Ohnishi, Michihito Kono, Masaru Kato, Kenji Oku, Olga Amengual, Tatsuya Atsumi, Morbidity and mortality in antiphospholipid syndrome based on cluster analysis: a 10-year longitudinal cohort study is available online at: https://doi.org/10.1093/rheumatology/keaa542
PISSN	1462-0324
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/rheumatology/keaa542