A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys

Sato, Takanori; Takakura, Aya; Lee, Ji-Won; Tokunaga, Kazuaki; Matsumori, Haruka; Takao-Kawabata, Ryoko; Iimura, Tadahiro

A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys

Sato, Takanori; Takakura, Aya; Lee, Ji-Won et al.

Microscopy, 2021, 70(6), 498-509

Permalink : https://hdl.handle.net/2115/84226

このアイテムのアクセス数:454件（2026-01-13 09:20 集計）

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https://doi.org/10.1093/jmicro/dfab020

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84226
タイトル	A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys
著者	Sato, Takanori ; Takakura, Aya ; Lee, Ji-Won ; Tokunaga, Kazuaki ; Matsumori, Haruka ; Takao-Kawabata, Ryoko ; Iimura, Tadahiro
著者名 Sato, Takanori
著者名 Takakura, Aya
e-Rad_Researcher 70711274 著者名 Lee, Ji-Won
著者名 Tokunaga, Kazuaki
著者名 Matsumori, Haruka
著者名 Takao-Kawabata, Ryoko
e-Rad_Researcher 20282775 著者名 Iimura, Tadahiro
言語	英語
キーワード	bone lamellarity
	collagen linearity
	multi-photon microscopy
	SHG (second harmonic generation)
	semi-automatic recognition
	teriparatide
発行日	2021-12
出版者	Oxford University Press
収録物名	Microscopy
巻(号)	70(6)
ページ	498-509
抄録	The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	2050-5698
関連情報	PMID 34100544
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1093/jmicro/dfab020