Hokkaido birth cohort study on environment and children’s health : cohort profile 2021

Kishi, Reiko; Ikeda-Araki, Atsuko; Miyashita, Chihiro; Itoh, Sachiko; Kobayashi, Sumitaka; Ait Bamai, Yu; Yamazaki, Keiko; Tamura, Naomi; Minatoya, Machiko; Ketema, Rahel Mesfin; Poudel, Kritika; Miura, Ryu; Masuda, Hideyuki; Itoh, Mariko; Yamaguchi, Takeshi; Fukunaga, Hisanori; Ito, Kumiko; Goudarzi, Houman

Hokkaido birth cohort study on environment and children’s health : cohort profile 2021

Kishi, Reiko; Ikeda-Araki, Atsuko; Miyashita, Chihiro et al.

Environmental Health and Preventive Medicine, 2021, 26(1), 59

Permalink : https://hdl.handle.net/2115/84242

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https://doi.org/10.1186/s12199-021-00980-y			5

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84242
タイトル	Hokkaido birth cohort study on environment and children’s health : cohort profile 2021
著者	Kishi, Reiko ; Ikeda-Araki, Atsuko ; Miyashita, Chihiro ; Itoh, Sachiko ; Kobayashi, Sumitaka ; Ait Bamai, Yu ; Yamazaki, Keiko ; Tamura, Naomi ; Minatoya, Machiko ; Ketema, Rahel Mesfin ; Poudel, Kritika ; Miura, Ryu ; Masuda, Hideyuki ; Itoh, Mariko ; Yamaguchi, Takeshi ; Fukunaga, Hisanori ; Ito, Kumiko ; Goudarzi, Houman
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
e-Rad_Researcher 00619885 著者名 Ikeda-Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
e-Rad_Researcher 90752907 著者名 Ait Bamai, Yu
e-Rad_Researcher 60732120 著者名 Yamazaki, Keiko
e-Rad_Researcher 80836164 著者名 Tamura, Naomi
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
著者名 Ketema, Rahel Mesfin
著者名 Poudel, Kritika
著者名 Miura, Ryu
著者名 Masuda, Hideyuki
著者名 Itoh, Mariko
著者名 Yamaguchi, Takeshi
e-Rad_Researcher 50781267 著者名 Fukunaga, Hisanori
著者名 Ito, Kumiko
著者名 Goudarzi, Houman
言語	英語
キーワード	Early life
	Environmental chemicals
	Secular trend
	Birth size
	Hormones
	Development
	Allergies andinfectious diseases
	Genetic polymorphisms
	Epigenetics
	DOHaD
発行日	2021-05-22
出版者	BioMed Central
収録物名	Environmental Health and Preventive Medicine
巻(号)	26(1)
ページ	59
抄録	Background:The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of twobirth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives areto (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birthdefects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioraldevelopmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-riskgroups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of variouschemicals, including tobacco.Methods:The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarizerecent results, and suggest future directions. In particular, this report provides the latest details from questionnairesurveys, face-to-face examinations, and a collection of biological specimens from children and measurements oftheir chemical exposures.Results:The latest findings indicate different risk factors of parental characteristics on birth outcomes and themediating effect between socioeconomic status and children that are small for the gestational age. Maternal serumfolate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birthsize and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones.We also found significant associations between the chemical levels and neuro development, asthma, and allergies.Conclusions:Chemical exposure to children can occur both before and after birth. Longer follow-up for children iscrucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast,considering shifts in the exposure levels due to regulation is also essential, which may also change the associationto health outcomes. This study found that individual susceptibility to adverse health effects depends on thegenotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examiningmolecular biology perspectives. International collaborations can add a new dimension to the current knowledgeand provide novel discoveries in the future.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1342-078X
EISSN	1347-4715
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12199-021-00980-y