Current trends of blood lead levels, distribution patterns and exposure variations among household members in Kabwe, Zambia

Yabe, John; Nakayama, Shouta M. M.; Nakata, Hokuto et al.

Chemosphere, 2020, 243, UNSP 125412

Permalink : https://hdl.handle.net/2115/84250

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アクセス権
open access
URI
https://hdl.handle.net/2115/84250
タイトル
Current trends of blood lead levels, distribution patterns and exposure variations among household members in Kabwe, Zambia
著者
Yabe, John ; Nakayama, Shouta M. M. ; Nakata, Hokuto ; Toyomaki, Haruya ; Yohannes, Yared B. ; Muzandu, Kaampwe ; Kataba, Andrew ; Zyambo, Golden ; Hiwatari, Masato ; Narita, Daiju ; Yamada, Daichi ; Hangoma, Peter ; Munyinda, Nosiku Sipilanyambe ; Mufune, Tiza ; Ikenaka, Yoshinori ; Choongo, Kennedy ; Ishizuka, Mayumi
著者名
Yabe, John
e-Rad_Researcher
90647629
著者名
Nakayama, Shouta M. M.
著者名
Nakata, Hokuto
著者名
Toyomaki, Haruya
著者名
Yohannes, Yared B.
著者名
Muzandu, Kaampwe
著者名
Kataba, Andrew
著者名
Zyambo, Golden
e-Rad_Researcher
50547172
著者名
Hiwatari, Masato
著者名
Narita, Daiju
著者名
Yamada, Daichi
著者名
Hangoma, Peter
著者名
Munyinda, Nosiku Sipilanyambe
著者名
Mufune, Tiza
e-Rad_Researcher
40543509
著者名
Ikenaka, Yoshinori
著者名
Choongo, Kennedy
e-Rad_Researcher
50332474
著者名
Ishizuka, Mayumi
言語
英語
キーワード
Childhood lead poisoning
LeadCare II analyser
Pb exposure differences
Kabwe
発行日
2020-03-01
出版者
Elsevier
収録物名
Chemosphere
巻(号)
243
ページ
UNSP 125412
抄録
Childhood lead (Pb) poisoning has devastating effects on neurodevelopment and causes overt clinical signs including convulsions and coma. Health effects including hypertension and various reproductive problems have been reported in adults. Historical Pb mining in Zambia's Kabwe town left a legacy of environmental pollution and childhood Pb poisoning. The current study aimed at establishing the extent of Pb poisoning and exposure differences among family members in Kabwe as well as determining populations at risk and identify children eligible for chelation therapy. Blood samples were collected in July and August 2017 from 1190 household members and Pb was measured using a portable LeadCare-II analyser. Participants included 291 younger children (3-months to 3-years-old), 271 older children (4-9-years-old), 412 mothers and 216 fathers from 13 townships with diverse levels of Pb contamination. The Blood Lead Levels (BLL) ranged from 1.65 to 162 mu g/dL, with residents from Kasanda (mean 45.7 mu g/dL) recording the highest BLL while Hamududu residents recorded the lowest (mean 3.3 mu g/dL). Of the total number of children sampled (n = 562), 23% exceeded the 45 mu g/dL, the threshold required for chelation therapy. A few children (5) exceeded the 100 mu g/dL whereas none of the parents exceeded the 100 mu g/dL value. Children had higher BLL than parents, with peak BLL-recorded at the age of 2-years-old. Lead exposure differences in Kabwe were attributed to distance and direction from the mine, with younger children at highest risk. Exposure levels in parents were equally alarming. For prompt diagnosis and treatment, a portable point-of-care devise such as a LeadCare-II would be preferable in Kabwe. (C) 2019 Elsevier Ltd. All rights reserved.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
0045-6535
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.chemosphere.2019.125412