Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury

Endo, Takeshi; Kadoya, Ken; Suzuki, Tomoaki; Suzuki, Yuki; Terkawi, Mohamad Alaa; Kawamura, Daisuke; Iwasaki, Norimasa

Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury

Endo, Takeshi; Kadoya, Ken; Suzuki, Tomoaki et al.

npj Regenerative Medicine, 2022, 7(1), 12

Permalink : https://hdl.handle.net/2115/84260

このアイテムのアクセス数:417件（2026-08-08 00:58 集計）

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https://doi.org/10.1038/s41536-022-00205-y			15

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/84260
タイトル	Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury
著者	Endo, Takeshi ; Kadoya, Ken ; Suzuki, Tomoaki ; Suzuki, Yuki ; Terkawi, Mohamad Alaa ; Kawamura, Daisuke ; Iwasaki, Norimasa
著者名 Endo, Takeshi
e-Rad_Researcher 30374276 著者名 Kadoya, Ken
著者名 Suzuki, Tomoaki
著者名 Suzuki, Yuki
著者名 Terkawi, Mohamad Alaa
著者名 Kawamura, Daisuke
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
発行日	2022-01-28
出版者	Nature Portfolio
収録物名	npj Regenerative Medicine
巻(号)	7(1)
ページ	12
抄録	Since Schwann cells (SCs) support axonal growth at development as well as after peripheral nerve injury (PNI), developing SCs might be able to promote axon regeneration after PNI. The purpose of the current study was to elucidate the capability of developing SCs to induce axon regeneration after PNI. SC precursors (SCPs), immature SCs (ISCs), repair SCs (RSCs) from injured nerves, and non-RSCs from intact nerves were tested by grafting into acellular region of rat sciatic nerve with crush injury. Both of developing SCs completely failed to support axon regeneration, whereas both of mature SCs, especially RSCs, induced axon regeneration. Further, RSCs but not SCPs promoted neurite outgrowth of adult dorsal root ganglion neurons. Transcriptome analysis revealed that the gene expression profiles were distinctly different between RSCs and SCPs. These findings indicate that developing SCs are markedly different from mature SCs in terms of functional and molecular aspects and that RSC is a viable candidate for regenerative cell therapy for PNI.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41536-022-00205-y