Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea

Kayasaki, Fumi; Okagawa, Tomohiro; Konnai, Satoru; Kohara, Junko; Sajiki, Yamato; Watari, Kei; Ganbaatar, Otgontuya; Goto, Shinya; Nakamura, Hayato; Shimakura, Honami; Minato, Erina; Kobayashi, Atsushi; Kubota, Manabu; Terasaki, Nobuhiro; Takeda, Akira; Noda, Haruka; Honma, Mitsuru; Maekawa, Naoya; Murata, Shiro; Ohashi, Kazuhiko

Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea

Kayasaki, Fumi; Okagawa, Tomohiro; Konnai, Satoru et al.

Veterinary microbiology, 2021, 254, 108976

Permalink : https://hdl.handle.net/2115/84266

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アクセス権	open access
URI	https://hdl.handle.net/2115/84266
タイトル	Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea
著者	Kayasaki, Fumi ; Okagawa, Tomohiro ; Konnai, Satoru ; Kohara, Junko ; Sajiki, Yamato ; Watari, Kei ; Ganbaatar, Otgontuya ; Goto, Shinya ; Nakamura, Hayato ; Shimakura, Honami ; Minato, Erina ; Kobayashi, Atsushi ; Kubota, Manabu ; Terasaki, Nobuhiro ; Takeda, Akira ; Noda, Haruka ; Honma, Mitsuru ; Maekawa, Naoya ; Murata, Shiro ; Ohashi, Kazuhiko
著者名 Kayasaki, Fumi
e-Rad_Researcher 80829036 著者名 Okagawa, Tomohiro
e-Rad_Researcher 40396304 著者名 Konnai, Satoru
著者名 Kohara, Junko
著者名 Sajiki, Yamato
著者名 Watari, Kei
著者名 Ganbaatar, Otgontuya
著者名 Goto, Shinya
著者名 Nakamura, Hayato
著者名 Shimakura, Honami
著者名 Minato, Erina
著者名 Kobayashi, Atsushi
著者名 Kubota, Manabu
著者名 Terasaki, Nobuhiro
著者名 Takeda, Akira
著者名 Noda, Haruka
著者名 Honma, Mitsuru
著者名 Maekawa, Naoya
e-Rad_Researcher 10579163 著者名 Murata, Shiro
e-Rad_Researcher 90250498 著者名 Ohashi, Kazuhiko
言語	英語
キーワード	Calf diarrhea
	Fermented milk replacer
	Lactic acid bacteria-supplemented milk replacer
	Rotavirus
	Enteritis
発行日	2021-03
出版者	Elsevier
収録物名	Veterinary microbiology
巻(号)	254
ページ	108976
抄録	Diarrhea is a major cause of death in calves and this is linked directly to economic loss in the cattle industry. Fermented milk replacer (FMR) has been used widely in clinical settings for calf feeding to improve its health and growth. However, the protective efficacy of FMR on calf diarrhea remains unclear. In this study, we verified the preventive effects of FMR feeding on calf diarrhea using an experimental infection model of bovine rotavirus (BRV) in newborn calves and a field study in dairy farms with calf diarrhea. In addition, we evaluated the protective efficacy of lactic acid bacteria-supplemented milk replacer (LAB-MR) in an experimental infection model. In the experimental infection, calves fed FMR or high-concentrated LAB-MR had diarrhea, but the water content of feces was lower and more stable than that of calves fed normal milk replacer. The amount of milk intake also decreased temporarily, but recovered immediately in the FMR- and LAB-MR-fed calves. As compared with the control calves, FMR- or LAB-MR-fed calves showed less severe or reduced histopathological lesions of enteritis in the intestinal mucosa. In a field study using dairy calves, FMR feeding significantly reduced the incidence of enteritis, mortality from enteritis, duration of a series of treatment for enteritis, number of consultations, and cost of medical care for the disease. These results suggest that feeding milk replacer-based probiotics to calves reduces the severity of diarrhea and tissue damage to the intestinal tract caused by BRV infection and provides significant clinical benefits to the prevention and treatment of calf diarrhea.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© <2021>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0378-1135
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.vetmic.2020.108976