Tuberculosis seroprevalence and comparison of hematology and biochemistry parameters between seropositive and seronegative captive Asian elephants of Nepal

Thapa, Jeewan; Mikota, Susan K.; Gairhe, Kamal Prasad; Paudel, Sarad; Singh, Dinesh Kumar; Dhakal, Ishwari Prasad; Nakajima, Chie; Suzuki, Yasuhiko

Tuberculosis seroprevalence and comparison of hematology and biochemistry parameters between seropositive and seronegative captive Asian elephants of Nepal

Thapa, Jeewan; Mikota, Susan K.; Gairhe, Kamal Prasad et al.

Journal of veterinary medical science, 2021, 83(8), 1278-1283

Permalink : https://hdl.handle.net/2115/84322

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https://doi.org/10.1292/jvms.21-0113

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84322
タイトル	Tuberculosis seroprevalence and comparison of hematology and biochemistry parameters between seropositive and seronegative captive Asian elephants of Nepal
著者	Thapa, Jeewan ; Mikota, Susan K. ; Gairhe, Kamal Prasad ; Paudel, Sarad ; Singh, Dinesh Kumar ; Dhakal, Ishwari Prasad ; Nakajima, Chie ; Suzuki, Yasuhiko
e-Rad_Researcher 40837449 著者名 Thapa, Jeewan
著者名 Mikota, Susan K.
著者名 Gairhe, Kamal Prasad
著者名 Paudel, Sarad
著者名 Singh, Dinesh Kumar
著者名 Dhakal, Ishwari Prasad
e-Rad_Researcher 60435964 著者名 Nakajima, Chie
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
言語	英語
キーワード	biochemistry
	elephant
	hematology
	seroprevalence
	tuberculosis
発行日	2021-08-12
出版者	公益社団法人日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名	Journal of veterinary medical science
巻(号)	83(8)
ページ	1278-1283
抄録	We conducted a tuberculosis (TB) serosurveillance program of captive elephants in Nepal and compared hematology and biochemistry parameters between seropositive and seronegative elephants. A total of 153 elephants (male=20, female=133) from four national parks were tested for TB using the ElephantTB STAT-PAK (R) Assay (ChemBio Diagnostic Systems, Inc., Medford, NY, USA). The mean reported age for 138 elephants was 38.5 years (range 2-71 years). Seroprevalence for TB was 21.56% (33/153). The majority of seropositive elephants were female (n=30) and from Chitwan National Park (n=29). The occurrence of TB seropositive cases in other more remote national parks suggests TB may be widespread among the captive elephant population of Nepal. Hematology and biochemistry analyses were performed on 13 and 22 seropositive elephants, respectively and, nine elephants from a seronegative TB herd for comparison. Hematology parameters (hemoglobin, packed cell volume, platelet, white blood cells, and erythrocyte sedimentation rate) were comparable between the two groups. Total protein, globulin, and lactate dehydrogenase were significantly higher in seronegative elephants, and bilirubin was significantly higher in seropositive elephants whereas blood urea nitrogen, creatinine, glutamic oxaloacetic transaminase/aspartate aminotransferase (GOT/AST), glutamic pyruvic transaminase/alanine aminotransferase (GPT/ALT), gamma glutamyl transferase (GT), and albumin were not significantly different. The range of biochemical parameters that were significantly different between seropositive and seronegative elephants had narrow ranges. Thus, the potential of these parameters as a direct biomarker for TB diagnosis is limited based on the findings in this study. We recommend including blood parameters in future TB surveillance studies.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0916-7250
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.21-0113