Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan

Suzuki, Akio; Sawada, Kazuhei; Erdenebat, Temuulen et al.

Journal of veterinary medical science, 2021, 83(11), 1735-1739

Permalink : https://hdl.handle.net/2115/84329

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https://doi.org/10.1292/jvms.21-0368     2

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アクセス権
metadata only access
URI
https://hdl.handle.net/2115/84329
タイトル
Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan
著者
Suzuki, Akio ; Sawada, Kazuhei ; Erdenebat, Temuulen ; Yamasaki, Takeshi ; Tobiume, Minoru ; Suga, Kinuyo ; Horiuchi, Motohiro
著者名
Suzuki, Akio
著者名
Sawada, Kazuhei
著者名
Erdenebat, Temuulen
著者名
Yamasaki, Takeshi
著者名
Tobiume, Minoru
著者名
Suga, Kinuyo
e-Rad_Researcher
30219216
著者名
Horiuchi, Motohiro
言語
英語
キーワード
chronic wasting disease
prion
prion protein
real-time quaking-induced conversion
scrapie
発行日
2021-11-16
出版者
公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名
Journal of veterinary medical science
巻(号)
83(11)
ページ
1735-1739
抄録
There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves's muntjac in Hokkaido and Honshu was tested for CWD prions. No CWD-positive cases were found, suggesting that CWD is nonexistent in Japan. Our results also indicate that RT-QuIC assay is useful for continuous monitoring of CWD. Furthermore, nucleotide sequence analysis of the PrP gene revealed sika deer in Japan harbor CWD susceptible allele.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0916-7250
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1292/jvms.21-0368