Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects

Kusumi, Ichiro; Masui, Takuya; Kakiuchi, Chihiro; Suzuki, Katsuji; Akimoto, Tatsuyuki; Hashimoto, Ryota; Kunugi, Hiroshi; Kato, Tadafumi; Kayama, Tsukasa

Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects

Kusumi, Ichiro; Masui, Takuya; Kakiuchi, Chihiro et al.

Neuroscience Letters, 2004, 369(1), 1-3

Permalink : https://hdl.handle.net/2115/8433

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アクセス権	open access
URI	https://hdl.handle.net/2115/8433
タイトル	Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
著者	Kusumi, Ichiro ; Masui, Takuya ; Kakiuchi, Chihiro ; Suzuki, Katsuji ; Akimoto, Tatsuyuki ; Hashimoto, Ryota ; Kunugi, Hiroshi ; Kato, Tadafumi ; Kayama, Tsukasa
e-Rad_Researcher 30250426 著者名 Kusumi, Ichiro
著者名 Masui, Takuya
著者名 Kakiuchi, Chihiro
著者名 Suzuki, Katsuji
著者名 Akimoto, Tatsuyuki
著者名 Hashimoto, Ryota
著者名 Kunugi, Hiroshi
著者名 Kato, Tadafumi
著者名 Kayama, Tsukasa
言語	英語
キーワード	Calcium
	XBP1
	Endoplamic reticulum
	Bipolar disorder
	Polymorphism
	Healthy subject
発行日	2004-10-07
出版者	Elsevier
収録物名	Neuroscience Letters
巻(号)	369(1)
ページ	1-3
記述	http://www.sciencedirect.com/science/journal/03043940
抄録	Dysregulations of calcium (Ca) homeostasis may be involved in the pathophysiology of bipolar disorder. Enhanced Ca response to various agonists in peripheral blood cells is one of a few confirmed biological markers for bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Thus, in this study, we examined the relationship between the XBP1 gene polymorphism and the Ca signaling in the platelets of healthy controls. The present results suggest no significant difference in the basal Ca level or 5-HT-induced Ca mobilization among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0304-3940
関連情報	PMID 15380296
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.neulet.2004.07.003