Interplay between Inflammation and Pathological Bone Resorption : Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

Terkawi, M. Alaa; Matsumae, Gen; Shimizu, Tomohiro; Takahashi, Daisuke; Kadoya, Ken; Iwasaki, Norimasa

Interplay between Inflammation and Pathological Bone Resorption : Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

Terkawi, M. Alaa; Matsumae, Gen; Shimizu, Tomohiro et al.

International Journal of Molecular Sciences, 2022, 23(3), 1786

Permalink : https://hdl.handle.net/2115/84462

このアイテムのアクセス数:465件（2026-02-13 22:48 集計）

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84462
タイトル	Interplay between Inflammation and Pathological Bone Resorption : Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives
著者	Terkawi, M. Alaa ; Matsumae, Gen ; Shimizu, Tomohiro ; Takahashi, Daisuke ; Kadoya, Ken ; Iwasaki, Norimasa
著者名 Terkawi, M. Alaa
著者名 Matsumae, Gen
e-Rad_Researcher 60784246 著者名 Shimizu, Tomohiro
e-Rad_Researcher 90528845 著者名 Takahashi, Daisuke
e-Rad_Researcher 30374276 著者名 Kadoya, Ken
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
キーワード	bone
	inflammation
	remodeling
	pathological bone resorption
	bone osteolytic diseases
発行日	2022-02-04
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	23(3)
ページ	1786
抄録	Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active organ that undergoes continuous remodeling processes to maintain its architecture, shape, and function throughout life. One of the most important medical discoveries of recent decades has been that the immune system is involved in bone remodeling. Indeed, chronic inflammation has been recognized as the most significant factor influencing bone homeostasis, causing a shift in the bone remodeling process toward pathological bone resorption. Bone osteolytic diseases typified by excessive bone resorption account for one of the greatest causes of disability worldwide, with significant economic and public health burdens. From this perspective, we discuss the recent findings and discoveries highlighting the cellular and molecular mechanisms that regulate this process in the bone microenvironment, in addition to the current therapeutic strategies for the treatment of osteolytic bone diseases.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijms23031786