Serotonin 5-HT2A receptor gene polymorphism, 5-HT2A receptor function and personality traits in healthy subjects: A negative study

Kusumi, Ichiro; Suzuki, Katsuji; Sasaki, Yuki; Kameda, Kensuke; Sasaki, Tsukasa; Koyama, Tsukasa

Serotonin 5-HT2A receptor gene polymorphism, 5-HT2A receptor function and personality traits in healthy subjects: A negative study

Kusumi, Ichiro; Suzuki, Katsuji; Sasaki, Yuki et al.

Journal of Affective Disorders, 2002, 68(2-3), 235-241

Permalink : https://hdl.handle.net/2115/8451

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アクセス権	open access
URI	https://hdl.handle.net/2115/8451
タイトル	Serotonin 5-HT2A receptor gene polymorphism, 5-HT2A receptor function and personality traits in healthy subjects: A negative study
著者	Kusumi, Ichiro ; Suzuki, Katsuji ; Sasaki, Yuki ; Kameda, Kensuke ; Sasaki, Tsukasa ; Koyama, Tsukasa
e-Rad_Researcher 30250426 著者名 Kusumi, Ichiro
著者名 Suzuki, Katsuji
著者名 Sasaki, Yuki
著者名 Kameda, Kensuke
著者名 Sasaki, Tsukasa
著者名 Koyama, Tsukasa
言語	英語
キーワード	Calcium
	Temperament and Character Inventory (TCI)
	Serotonin-2A receptor function
	Serotonin-2A receptor gene polymorphism
	Personality trait
	Healthy subject
発行日	2002-04
出版者	Elsevier
収録物名	Journal of Affective Disorders
巻(号)	68(2-3)
ページ	235-241
抄録	Background -- Central serotonin-2A (5-HT2A) receptor dysfunction is regarded as an important factor in the etiology of affective disorders. The relations between some personality traits and the vulnerability of affective disorders are also implicated. Moreover, there are several reports which describe the association between 5-HT2A receptor gene polymorphisms and mental disorders. We therefore examined the relationship between personality traits, the 5-HT2A receptor function, and 5-HT2A receptor gene polymorphisms. Methods -- 5-HT-induced intraplatelet calcium (Ca) mobilization, 5-HT2A receptor gene polymorphisms (A-1438G, T102C, T516C, C1340T, C1354T), and Temperament and Character Inventory (TCI) scores were examined in 133 healthy subjects. Results -- Neither 5-HT-induced Ca mobilization nor 5-HT2A receptor gene polymorphisms (A-1438G, T102C) appear to be associated with seven personality dimensions including Harm Avoidance. There was no significant difference in the Ca response among the subjects with -1438A/A, A/G and G/G genotypes. Since the appearance of the other types of the 5-HT2A receptor gene polymorphisms (T516C, C1340T and C1354T) was quite rare in our sample, we were unable to examine the relationship between these polymorphisms, and the TCI score or the Ca response. Limitations -- Our failure to find a significant association may reflect the false negative results due to the small sample size and low statistical power. Further studies in depressed patients may clarify the complicated relationship between personality traits and the vulnerability of affective disorders. Conclusions -- Personality traits detected by TCI may not be directly related to the 5-HT2A receptor function or 5-HT2A receptor gene polymorphism which may be involved in the vulnerability of affective disorders.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0165-0327
関連情報	URI http://www.sciencedirect.com/science/journal/01650327
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/S0165-0327(00)00324-4