GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

Iwasaki, Yusaku; Sendo, Mio; Dezaki, Katsuya; Hira, Tohru; Sato, Takehiro; Nakata, Masanori; Goswami, Chayon; Aoki, Ryohei; Arai, Takeshi; Kumari, Parmila; Hayakawa, Masaki; Masuda, Chiaki; Okada, Takashi; Hara, Hiroshi; Drucker, Daniel J.; Yamada, Yuichiro; Tokuda, Masaaki; Yada, Toshihiko

GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

Iwasaki, Yusaku; Sendo, Mio; Dezaki, Katsuya et al.

Nature Communications, 2018, 9(1), 113

Permalink : https://hdl.handle.net/2115/84547

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アクセス権	open access
URI	https://hdl.handle.net/2115/84547
タイトル	GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
著者	Iwasaki, Yusaku ; Sendo, Mio ; Dezaki, Katsuya ; Hira, Tohru ; Sato, Takehiro ; Nakata, Masanori ; Goswami, Chayon ; Aoki, Ryohei ; Arai, Takeshi ; Kumari, Parmila ; Hayakawa, Masaki ; Masuda, Chiaki ; Okada, Takashi ; Hara, Hiroshi ; Drucker, Daniel J. ; Yamada, Yuichiro ; Tokuda, Masaaki ; Yada, Toshihiko
著者名 Iwasaki, Yusaku
著者名 Sendo, Mio
著者名 Dezaki, Katsuya
e-Rad_Researcher 10396301 著者名 Hira, Tohru
著者名 Sato, Takehiro
著者名 Nakata, Masanori
著者名 Goswami, Chayon
著者名 Aoki, Ryohei
著者名 Arai, Takeshi
著者名 Kumari, Parmila
著者名 Hayakawa, Masaki
著者名 Masuda, Chiaki
著者名 Okada, Takashi
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
著者名 Drucker, Daniel J.
著者名 Yamada, Yuichiro
著者名 Tokuda, Masaaki
著者名 Yada, Toshihiko
言語	英語
発行日	2018
収録物名	Nature Communications
巻(号)	9(1)
ページ	113
抄録	Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar D-allulose (D-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models. Subchronic D-allulose administered at the light period (LP) onset ameliorates LP-specific hyperphagia, visceral obesity, and glucose intolerance. These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents. Our results identify D-allulose as prominent GLP-1 releaser that acts via vagal afferents to restrict feeding and hyperglycemia. Furthermore, when administered in a time-specific manner, chronic D-allulose corrects arrhythmic overeating, obesity and diabetes, suggesting that chronotherapeutic modulation of vagal afferent GLP-1R signaling may aid in treating metabolic disorders.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	2041-1723
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41467-017-02488-y