GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

Iwasaki, Yusaku; Sendo, Mio; Dezaki, Katsuya et al.

Nature Communications, 2018, 9(1), 113

Permalink : https://hdl.handle.net/2115/84547

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アクセス権
open access
URI
https://hdl.handle.net/2115/84547
タイトル
GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose
著者
Iwasaki, Yusaku ; Sendo, Mio ; Dezaki, Katsuya ; Hira, Tohru ; Sato, Takehiro ; Nakata, Masanori ; Goswami, Chayon ; Aoki, Ryohei ; Arai, Takeshi ; Kumari, Parmila ; Hayakawa, Masaki ; Masuda, Chiaki ; Okada, Takashi ; Hara, Hiroshi ; Drucker, Daniel J. ; Yamada, Yuichiro ; Tokuda, Masaaki ; Yada, Toshihiko
著者名
Iwasaki, Yusaku
著者名
Sendo, Mio
著者名
Dezaki, Katsuya
e-Rad_Researcher
10396301
著者名
Hira, Tohru
著者名
Sato, Takehiro
著者名
Nakata, Masanori
著者名
Goswami, Chayon
著者名
Aoki, Ryohei
著者名
Arai, Takeshi
著者名
Kumari, Parmila
著者名
Hayakawa, Masaki
著者名
Masuda, Chiaki
著者名
Okada, Takashi
e-Rad_Researcher
70198894
著者名
Hara, Hiroshi
著者名
Drucker, Daniel J.
著者名
Yamada, Yuichiro
著者名
Tokuda, Masaaki
著者名
Yada, Toshihiko
言語
英語
発行日
2018
収録物名
Nature Communications
巻(号)
9(1)
ページ
113
抄録
Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar D-allulose (D-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models. Subchronic D-allulose administered at the light period (LP) onset ameliorates LP-specific hyperphagia, visceral obesity, and glucose intolerance. These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents. Our results identify D-allulose as prominent GLP-1 releaser that acts via vagal afferents to restrict feeding and hyperglycemia. Furthermore, when administered in a time-specific manner, chronic D-allulose corrects arrhythmic overeating, obesity and diabetes, suggesting that chronotherapeutic modulation of vagal afferent GLP-1R signaling may aid in treating metabolic disorders.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
EISSN
2041-1723
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1038/s41467-017-02488-y