open access

https://hdl.handle.net/2115/84587

What Is GLP-1 Really Doing in Obesity?

英語

postprandial response

2020

Trends in Endocrinology & Metabolism

31(2)

71-80

GLP-1 is an antidiabetic hormone released from the gut in response to nutrient ingestion. Many studies have evaluated whether GLP-1 secretion is reduced, increased, or neither in the obese, glucose-intolerant (impaired glucose tolerance), or diabetic status. In human and animal studies, reduced GLP-1 secretion in response to nutritional stimulation was reported, while unchanged or increased GLP-1 responses were also demonstrated. By monitoring nutrient-induced GLP-1 secretion over time during diet-induced obesity development in rats, we reproducibly showed that GLP-1 secretion was enhanced in diet-induced obese rats compared with control rats. These inconsistent outcomes were obtained under various experimental conditions and more studies are needed to understand the mechanisms underlying adaptive changes in the GLP-1 secretory system during obesity or diabetes development. Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released in response to meal ingestion and enhances insulin secretion from pancreatic β cells. In several human studies, GLP-1 secretory responses to oral glucose load or a meal were decreased in subjects with obesity, glucose intolerance, or diabetes compared with those in healthy subjects. However, the results of meta-analysis and cohort studies do not necessarily support this concept. Results from animal studies are also inconsistent; in multiple studies, GLP-1 secretory responses to a meal were repeatedly higher in diet-induced obese rats than in control rats. Thus, the postprandial GLP-1 response is not necessarily decreased but rather enhanced during obesity development, which is likely to play a protective role against glucose intolerance.

学術雑誌論文

Version of Record

1043-2760