Prenatal exposure to 11 perfluoroalkyl substances and fetal growth : A large-scale, prospective birth cohort study

Kashino, Ikuko; Sasaki, Seiko; Okada, Emiko; Matsuura, Hideyuki; Goudarzi, Houman; Miyashita, Chihiro; Okada, Eisaku; Ito, Yoichi M.; Araki, Atsuko; Kishi, Reiko

Prenatal exposure to 11 perfluoroalkyl substances and fetal growth : A large-scale, prospective birth cohort study

Kashino, Ikuko; Sasaki, Seiko; Okada, Emiko et al.

Environment International, 2020, 136, 105355

Permalink : https://hdl.handle.net/2115/84598

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https://doi.org/10.1016/j.envint.2019.105355

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84598
タイトル	Prenatal exposure to 11 perfluoroalkyl substances and fetal growth : A large-scale, prospective birth cohort study
著者	Kashino, Ikuko ; Sasaki, Seiko ; Okada, Emiko ; Matsuura, Hideyuki ; Goudarzi, Houman ; Miyashita, Chihiro ; Okada, Eisaku ; Ito, Yoichi M. ; Araki, Atsuko ; Kishi, Reiko
著者名 Kashino, Ikuko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
著者名 Okada, Emiko
著者名 Matsuura, Hideyuki
e-Rad_Researcher 40713607 著者名 Goudarzi, Houman
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Okada, Eisaku
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Birth weight
	Perfluoroalkyl substances (PFAS)
	Perfluorononanoic acid (PFNA)
	Perfluorooctane sulfonate (PFOS)
	Perfluorooctanoic acid (PFOA)
	Pregnancy
発行日	2020-03
出版者	Elsevier
収録物名	Environment International
巻(号)	136
ページ	105355
抄録	Background:Prenatal maternal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)has been reportedly associated with decreased birth weight. Although a majority of epidemiological studiesconcerning perfluoroalkyl substances (PFAS) have focused on PFOS and PFOA, epidemiological studies of PFASwith longer carbon chains are scarce. In this study, we investigated whether prenatal maternal exposure to 11PFAS, in particular those with longer carbon chains, is associated with fetal growth.Methods:The study included 1985 mother-infant pairs (inclusive of preterm and post-term infants), who en-rolled in a large-scale, prospective birth cohort study in any of the 37 hospitals in Hokkaido, Japan between2003 and 2009. The concentration of 11 PFAS was measured in maternal plasma collected during the thirdtrimester of pregnancy, using ultra-performance liquid chromatography in combination with triple quadrupolemass spectrometry. Associations between the measured PFAS values and weight, length, and head circumferenceof all newborns at birth were examined using multiple regression analyses with adjustment for potential con-founders based on data collected from medical records, questionnaires, and those for maternal plasma samples.Results:Of the 11 PFAS analyzed, prenatal perfluorononanoic acid (PFNA) [per log10-unit: regression coefficient(β) = −96.2 g, 95% confidence intervals (95% CI), −165.3 to −27.1] and perfluorodecanoic acid (PFDA)(β = −72.2 g, 95% CI, −138.1 to −6.3) concentrations were inversely associated with birth weight.Furthermore, PFNA concentrations were inversely associated with birth length (per Log10unit: β = −0.48 cm,95% CI; − 0.86 to −0.11). Maternal perfluorotridecanoic acid (PFTrDA) exposure showed a significant inverseassociation with birth weight only for female infants (per Log10unit: β = −99.8 g, 95% CI, − 193.7 to −6.0) (Pfor interaction = 0.04).Conclusions:Our findings suggest that prenatal, maternal exposure to PFAS with longer carbon chains tends tobe inversely associated with birth size of newborn infants, which may indicate that these commercially usedcompounds have an adverse effect on fetal growth.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0160-4120
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.envint.2019.105355