Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : a cross-sectional study

Jia, Xiaofang; Tagawa, Masahiro; Yatsuya, Hiroshi; Naito, Hisao; Hayashi, Yumi; Yetti, Husna; Sasaki, Seiko; Araki, Atsuko; Miyashita, Chihiro; Ikeno, Tamiko; Kishi, Reiko; Nakajima, Tamie

Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : a cross-sectional study

Jia, Xiaofang; Tagawa, Masahiro; Yatsuya, Hiroshi et al.

Journal of Perinatal Medicine, 2015, 43(5), 565-575

Permalink : https://hdl.handle.net/2115/84613

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アクセス権	open access
URI	https://hdl.handle.net/2115/84613
タイトル	Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : a cross-sectional study
著者	Jia, Xiaofang ; Tagawa, Masahiro ; Yatsuya, Hiroshi ; Naito, Hisao ; Hayashi, Yumi ; Yetti, Husna ; Sasaki, Seiko ; Araki, Atsuko ; Miyashita, Chihiro ; Ikeno, Tamiko ; Kishi, Reiko ; Nakajima, Tamie
著者名 Jia, Xiaofang
著者名 Tagawa, Masahiro
著者名 Yatsuya, Hiroshi
著者名 Naito, Hisao
著者名 Hayashi, Yumi
著者名 Yetti, Husna
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
著者名 Nakajima, Tamie
言語	英語
キーワード	Association study
	fatty acid status
	pregnancy
	term birth outcomes
発行日	2015-09-01
出版者	De Gruyter
収録物名	Journal of Perinatal Medicine
巻(号)	43(5)
ページ	565-575
抄録	Objective: To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions. Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study. Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35–41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35–41 gestational weeks than those at 23–31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95% confidence interval (CI): 0.006, 0.556] at 35–41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA. Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	The final publication is available at www.degruyter.com
PISSN	0300-5577
EISSN	1619-3997
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1515/jpm-2014-0277