Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration : A Review

Ohnishi, Takashi; Iwasaki, Norimasa; Sudo, Hideki

Cells, 2022, 11(3), 394

Permalink : https://hdl.handle.net/2115/84687

このアイテムのアクセス数:439件（2026-02-12 01:17 集計）

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https://doi.org/10.3390/cells11030394     1

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アクセス権
metadata only access
URI
https://hdl.handle.net/2115/84687
タイトル
Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration : A Review
著者
Ohnishi, Takashi ; Iwasaki, Norimasa ; Sudo, Hideki
著者名
Ohnishi, Takashi
e-Rad_Researcher
30322803
著者名
Iwasaki, Norimasa
e-Rad_Researcher
30374367
著者名
Sudo, Hideki
言語
英語
キーワード
intervertebral disc degeneration
apoptosis
necroptosis
pyroptosis
ferroptosis
small interfering RNA (siRNA)
microRNA (miR)
long non-coding RNA (lncRNA)
circular RNA (circRNA)
発行日
2022-02
出版者
MDPI
収録物名
Cells
巻(号)
11(3)
ページ
394
抄録
Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms indirectly. Numerous studies have been performed to date, and the major strategy for all treatments of IVDD is to prevent cell loss due to programmed or regulated cell death. Accumulating evidence suggests that several types of cell death other than apoptosis, including necroptosis, pyroptosis, and ferroptosis, are also involved in IVDD. In this study, we discuss the molecular pathway of each type of cell death and review the literature that has identified their role in IVDD. We also summarize the recent advances in targeted therapy at the RNA level, including RNA modulations through RNA interference and regulation of non-coding RNAs, for preventing cell death and subsequent IVDD. Therefore, we review the causes and possible therapeutic targets for RNA intervention and discuss the future direction of this research field.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
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出版社版DOI
https://doi.org/10.3390/cells11030394