Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells

Tsujioka, Takao; Sasaki, Daisuke; Takeda, Atsuhito; Harashima, Hideyoshi; Yamada, Yuma

Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells

Tsujioka, Takao; Sasaki, Daisuke; Takeda, Atsuhito et al.

International Journal of Molecular Sciences, 2021, 23(1), 112

Permalink : https://hdl.handle.net/2115/84697

このアイテムのアクセス数:496件（2026-02-18 21:56 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.3390/ijms23010112

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84697
タイトル	Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells
著者	Tsujioka, Takao ; Sasaki, Daisuke ; Takeda, Atsuhito ; Harashima, Hideyoshi ; Yamada, Yuma
著者名 Tsujioka, Takao
著者名 Sasaki, Daisuke
e-Rad_Researcher 00374413 著者名 Takeda, Atsuhito
e-Rad_Researcher 00183567 著者名 Harashima, Hideyoshi
e-Rad_Researcher 60451431 著者名 Yamada, Yuma
言語	英語
キーワード	mitochondria
	myocardial cells
	liposome
	mitochondrial delivery
	mitochondrial respiratory capacity
	resveratrol
発行日	2021-12-22
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	23(1)
ページ	112
抄録	The development of drug delivery systems for use in the treatment of cardiovascular diseases is an area of great interest. We report herein on an evaluation of the therapeutic potential of a myocardial mitochondria-targeting liposome, a multifunctional envelope-type nano device for targeting pancreatic beta cells (beta-MEND) that was previously developed in our laboratory. Resveratrol (RES), a natural polyphenol compound that has a cardioprotective effect, was encapsulated in the beta-MEND (beta-MEND (RES)), and its efficacy was evaluated using rat myocardioblasts (H9c2 cells). The beta-MEND (RES) was readily taken up by H9c2 cells, as verified by fluorescence-activated cell sorter data, and was observed to be colocalized with intracellular mitochondria by confocal laser scanning microscopy. Myocardial mitochondrial function was evaluated by a Seahorse XF Analyzer and the results showed that the beta-MEND (RES) significantly activated cellular maximal respiratory capacity. In addition, the beta-MEND (RES) showed no cellular toxicity for H9c2 cells as evidenced by Premix WST-1 assays. This is the first report of the use of a myocardial mitochondria-targeting liposome encapsulating RES for activating mitochondrial function, which was clearly confirmed based on analyses using a Seahorse XF Analyzer.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
EISSN	1422-0067
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijms23010112