Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis

Sasaki, Yuto; Saitoh, Kodai; Kagohashi, Kota; Kitai, Yuichi; Muromoto, Ryuta; Oritani, Kenji; Kashiwakura, Jun-Ichi; Matsuda, Tadashi

Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis

Sasaki, Yuto; Saitoh, Kodai; Kagohashi, Kota et al.

Biological & pharmaceutical bulletin, 2021, 44(12), 1898-1901

Permalink : https://hdl.handle.net/2115/84699

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84699
タイトル	Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis
著者	Sasaki, Yuto ; Saitoh, Kodai ; Kagohashi, Kota ; Kitai, Yuichi ; Muromoto, Ryuta ; Oritani, Kenji ; Kashiwakura, Jun-Ichi ; Matsuda, Tadashi
著者名 Sasaki, Yuto
著者名 Saitoh, Kodai
著者名 Kagohashi, Kota
e-Rad_Researcher 90756165 著者名 Kitai, Yuichi
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
e-Rad_Researcher 70324762 著者名 Oritani, Kenji
e-Rad_Researcher 90373290 著者名 Kashiwakura, Jun-Ichi
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	signal-transducing adaptor protein-2
	autoimmune hepatitis
	interferon-γ (IFN-γ)
	Fas ligand (FasL)
	caspase-3
発行日	2021-12-01
出版者	The Pharmaceutical Society of Japan
出版者	日本薬学会
収録物名	Biological & pharmaceutical bulletin
巻(号)	44(12)
ページ	1898-1901
抄録	Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis. After intravenous injection of concanavalin A (ConA), STAP-2 knock out (KO) mice showed more severe liver necrosis along with substantial lymphocyte infiltration compared to wild type (WT) mice. Serum alanine aminotransferase levels were significantly higher in ConA-injected STAP-2 KO mice than in WT mice. Levels of interferon-gamma (IFN-gamma), an important factor for liver necrosis, were also significantly increased in sera of STAP-2 KO mice compared to WT mice after ConA injection. Statistically significant upregulation of Fas ligand (FasL) expression was observed in the livers of ConA-injected STAP-2 KO mice compared to WT mice. In accordance with these results, apoptotic signals were facilitated in STAP-2 KO mice compared to WT mice after ConA injection. Correctively, these results suggest that STAP-2 is involved in the pathogenesis of autoimmune hepatitis by regulating the expression of FasL and the production of IFN-gamma.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-6158
EISSN	1347-5215
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/bpb.b21-00595