Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis

Sasaki, Yuto; Saitoh, Kodai; Kagohashi, Kota et al.

Biological & pharmaceutical bulletin, 2021, 44(12), 1898-1901

Permalink : https://hdl.handle.net/2115/84699

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アクセス権
open access
URI
https://hdl.handle.net/2115/84699
タイトル
Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis
著者
Sasaki, Yuto ; Saitoh, Kodai ; Kagohashi, Kota ; Kitai, Yuichi ; Muromoto, Ryuta ; Oritani, Kenji ; Kashiwakura, Jun-Ichi ; Matsuda, Tadashi
著者名
Sasaki, Yuto
著者名
Saitoh, Kodai
著者名
Kagohashi, Kota
e-Rad_Researcher
90756165
著者名
Kitai, Yuichi
e-Rad_Researcher
30455597
著者名
Muromoto, Ryuta
e-Rad_Researcher
70324762
著者名
Oritani, Kenji
e-Rad_Researcher
90373290
著者名
Kashiwakura, Jun-Ichi
e-Rad_Researcher
20212219
著者名
Matsuda, Tadashi
言語
英語
キーワード
signal-transducing adaptor protein-2
autoimmune hepatitis
interferon-γ (IFN-γ)
Fas ligand (FasL)
caspase-3
発行日
2021-12-01
出版者
The Pharmaceutical Society of Japan
日本薬学会
収録物名
Biological & pharmaceutical bulletin
巻(号)
44(12)
ページ
1898-1901
抄録
Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis. After intravenous injection of concanavalin A (ConA), STAP-2 knock out (KO) mice showed more severe liver necrosis along with substantial lymphocyte infiltration compared to wild type (WT) mice. Serum alanine aminotransferase levels were significantly higher in ConA-injected STAP-2 KO mice than in WT mice. Levels of interferon-gamma (IFN-gamma), an important factor for liver necrosis, were also significantly increased in sera of STAP-2 KO mice compared to WT mice after ConA injection. Statistically significant upregulation of Fas ligand (FasL) expression was observed in the livers of ConA-injected STAP-2 KO mice compared to WT mice. In accordance with these results, apoptotic signals were facilitated in STAP-2 KO mice compared to WT mice after ConA injection. Correctively, these results suggest that STAP-2 is involved in the pathogenesis of autoimmune hepatitis by regulating the expression of FasL and the production of IFN-gamma.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0918-6158
EISSN
1347-5215
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/bpb.b21-00595