Integral radiation dose to normal structures with conformal external beam radiation

Aoyama, Hidefumi; Westerly, David Clark; Mackie, Thomas Rockwell; Olivera, Gustavo H.; Bentzen, Soren M.; Patel, Rakesh R.; Jaradat, Hazim; Tome, Wolfgang A.; Ritter, Mark A.; Mehta, Minesh P.

Integral radiation dose to normal structures with conformal external beam radiation

Aoyama, Hidefumi; Westerly, David Clark; Mackie, Thomas Rockwell et al.

International Journal of Radiation Oncology Biology Physics, 2006, 64(3), 962-967

Permalink : https://hdl.handle.net/2115/8470

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アクセス権	open access
URI	https://hdl.handle.net/2115/8470
タイトル	Integral radiation dose to normal structures with conformal external beam radiation
その他のタイトル	Normal Integral dose of IMRT and tomotherapy
著者	Aoyama, Hidefumi ; Westerly, David Clark ; Mackie, Thomas Rockwell ; Olivera, Gustavo H. ; Bentzen, Soren M. ; Patel, Rakesh R. ; Jaradat, Hazim ; Tome, Wolfgang A. ; Ritter, Mark A. ; Mehta, Minesh P.
著者名 Aoyama, Hidefumi
著者名 Westerly, David Clark
著者名 Mackie, Thomas Rockwell
著者名 Olivera, Gustavo H.
著者名 Bentzen, Soren M.
著者名 Patel, Rakesh R.
著者名 Jaradat, Hazim
著者名 Tome, Wolfgang A.
著者名 Ritter, Mark A.
著者名 Mehta, Minesh P.
言語	英語
キーワード	Radiation
	IMRT
	Tomotherapy
	Prostrate cancer
	Integral dose
発行日	2006-03
出版者	Elsevier
収録物名	International Journal of Radiation Oncology Biology Physics
巻(号)	64(3)
ページ	962-967
抄録	Background: This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity modulated radiotherapy (IMRT) for prostate cancer. Materials and Methods: Twenty-five radiation treatment plans, including MRT using a conventional linac with both 6 (6MV-IMRT) and 20 MV (20MV-IMRT) as well as 3DCRT using 6 (6MV-3DCRT) and 20 MV (20MV-3DCRT), and IMRT using tomotherapy (6MV) (Tomo-IMRT), were created for five patients with localized prostate cancer. The ID (mean dose X tissue volume) received by normal tissue (NTID) was calculated from dose-volume histograms. Results: 6MV-IMRT resulted in 5.0% lower NTID than 6MV-3DCRT; 20MV beam plans resulted in 7.7-11.2% lower NTID than 6 MV-3DCRT. Tomo-IMRT NTID was comparable to 6 MV-IMRT. Compared to 6MV-3DCRT, 6MV-IMRT reduced IDs to the rectal wall and penile bulb by 6.1% and 2.7%, respectively. Tomo-IMRT further reduced these IDs by 11.9% and 16.5%, respectively. 20MV did not reduce IDs to those structures. Conclusions: The difference of NTID between 3DCRT and IMRT is small. 20MV plans somewhat reduced NTID compared to 6MV plans. The advantage of tomotherapy over conventional IMRT and 3DCRT for localized prostate cancer was demonstrated in regard to dose sparing of rectal wall and penile bulb without increasing NTID.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	03603016
NCID	AA00680920
関連情報	URI http://www.sciencedirect.com/science/journal/03603016
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ijrobp.2005.11.005