Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead : A Preliminary Study

Nakata, Hokuto; Eguchi, Akifumi; Nakayama, Shouta M. M.; Yabe, John; Muzandu, Kaampwe; Ikenaka, Yoshinori; Mori, Chisato; Ishizuka, Mayumi

Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead : A Preliminary Study

Nakata, Hokuto; Eguchi, Akifumi; Nakayama, Shouta M. M. et al.

International journal of environmental research and public health, 2022, 19(1), 541

Permalink : https://hdl.handle.net/2115/84737

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https://doi.org/10.3390/ijerph19010541			1

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/84737
タイトル	Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead : A Preliminary Study
著者	Nakata, Hokuto ; Eguchi, Akifumi ; Nakayama, Shouta M. M. ; Yabe, John ; Muzandu, Kaampwe ; Ikenaka, Yoshinori ; Mori, Chisato ; Ishizuka, Mayumi
e-Rad_Researcher 60815273 著者名 Nakata, Hokuto
著者名 Eguchi, Akifumi
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Yabe, John
著者名 Muzandu, Kaampwe
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
著者名 Mori, Chisato
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	lead
	metabolomics
	wild rodent
	mining
	biomarker
	biological pathway
	lasso regression model
	random forest model
発行日	2022-01
出版者	MDPI
収録物名	International journal of environmental research and public health
巻(号)	19(1)
ページ	541
抄録	Lead poisoning is often considered a traditional disease; however, the specific mechanism of toxicity remains unclear. The study of Pb-induced alterations in cellular metabolic pathways is important to understand the biological response and disorders associated with environmental exposure to lead. Metabolomics studies have recently been paid considerable attention to understand in detail the biological response to lead exposure and the associated toxicity mechanisms. In the present study, wild rodents collected from an area contaminated with lead (N = 18) and a control area (N = 10) were investigated. This was the first ever experimental metabolomic study of wildlife exposed to lead in the field. While the levels of plasma phenylalanine and isoleucine were significantly higher in a lead-contaminated area versus the control area, hydroxybutyric acid was marginally significantly higher in the contaminated area, suggesting the possibility of enhancement of lipid metabolism. In the interregional least-absolute shrinkage and selection operator (lasso) regression model analysis, phenylalanine and isoleucine were identified as possible biomarkers, which is in agreement with the random forest model. In addition, in the random forest model, glutaric acid, glutamine, and hydroxybutyric acid were selected. In agreement with previous studies, enrichment analysis showed alterations in the urea cycle and ATP-binding cassette transporter pathways. Although regional rodent species bias was observed in this study, and the relatively small sample size should be taken into account, the present results are to some extent consistent with those of previous studies on humans and laboratory animals.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1660-4601
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijerph19010541