Disordered Expression of HOX Genes in Human Non-Small Cell Lung Cancer

Abe, Motoki; Hamada, Jun-ichi; Takahashi, Osamu et al.

ONCOLOGY REPORTS, 2006, 15(4), 797-802

Permalink : https://hdl.handle.net/2115/8484

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アクセス権
open access
URI
https://hdl.handle.net/2115/8484
タイトル
Disordered Expression of HOX Genes in Human Non-Small Cell Lung Cancer
著者
Abe, Motoki ; Hamada, Jun-ichi ; Takahashi, Osamu ; Takahashi, Yoko ; Tada, Mitsuhiro ; Miyamoto, Masaki ; Morikawa, Toshiaki ; Kondo, Satoshi ; Moriuchi, Tetsuya
著者名
Abe, Motoki
著者名
Hamada, Jun-ichi
著者名
Takahashi, Osamu
著者名
Takahashi, Yoko
著者名
Tada, Mitsuhiro
著者名
Miyamoto, Masaki
著者名
Morikawa, Toshiaki
e-Rad_Researcher
30215454
著者名
Kondo, Satoshi
著者名
Moriuchi, Tetsuya
言語
英語
キーワード
Homeobox gene
HOX
Real-time RT-PCR
Lung cancer
発行日
2006-04
出版者
PROFESSOR D A SPANDIDOS
収録物名
ONCOLOGY REPORTS
巻(号)
15(4)
ページ
797-802
抄録
We hypothesized that the disordered tissue architecture in cancer results from the steps that the cells execute the program designed during ontogeny in a spatiotemporally inappropriate manner. HOX genes are known as master regulators of embryonic morphogenesis, and encode transcription factors which regulate the transcription of the downstream genes to realize the program of body plan. In this study, we quantified the expression levels of 39 HOX genes in 41 human non-small cell lung cancer (non-SCLC) and non-cancerous lung tissues by a comprehensive analysis system based on the realtime RT-PCR method. We found that the expression levels of HOXA1, A5, A10 and C6 in squamous cell carcinoma tissues (and HOXA5 and A10 in adenocarcinoma tissues) were significantly higher than those in the non-cancerous tissues. Comparison of HOX gene expressions between adenocarcinoma and squamous cell carcinoma tissues showed higher expressions of HOXA1, D9, D10 and D11 in squamous cell carcinoma tissues than in adenocarcinoma tissues. Immunohistochemical analysis revealed that HOXA5 and A10 proteins were localized in the cytoplasm of tumor cells in both adenocarcinoma and squamous cell carcinoma tissues. These results suggest that the disordered patterns of HOX gene expressions were involved in not only the development of non-SCLC but also histological diversity such as adenocarcinoma and squamous cell carcinoma.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1021-335X