Controlled release, antimicrobial activity, and oral mucosa irritation of cetylpyridinium chloride-montmorillonite incorporated in a tissue conditioner

Asahara, Erika; Abe, Yasuhiko; Nakamori, Kiichi; Okazaki, Yohei; Makita, Yoji; Hasebe, Akira; Tsuga, Kazuhiro; Yokoyama, Atsuro

Controlled release, antimicrobial activity, and oral mucosa irritation of cetylpyridinium chloride-montmorillonite incorporated in a tissue conditioner

Asahara, Erika; Abe, Yasuhiko; Nakamori, Kiichi et al.

Dental materials journal, 2022, 41(1), 142-149

Permalink : https://hdl.handle.net/2115/85083

このアイテムのアクセス数:529件（2026-02-10 14:09 集計）

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https://doi.org/10.4012/dmj.2021-155			3

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/85083
タイトル	Controlled release, antimicrobial activity, and oral mucosa irritation of cetylpyridinium chloride-montmorillonite incorporated in a tissue conditioner
著者	Asahara, Erika ; Abe, Yasuhiko ; Nakamori, Kiichi ; Okazaki, Yohei ; Makita, Yoji ; Hasebe, Akira ; Tsuga, Kazuhiro ; Yokoyama, Atsuro
著者名 Asahara, Erika
e-Rad_Researcher 00253097 著者名 Abe, Yasuhiko
著者名 Nakamori, Kiichi
e-Rad_Researcher 00706898 著者名 Okazaki, Yohei
e-Rad_Researcher 80357988 著者名 Makita, Yoji
e-Rad_Researcher 90281815 著者名 Hasebe, Akira
e-Rad_Researcher 60217289 著者名 Tsuga, Kazuhiro
e-Rad_Researcher 20210627 著者名 Yokoyama, Atsuro
言語	英語
キーワード	Tissue conditioner
	Cetylpyridinium chloride (CPC)
	Release test
	Antimicrobial
	Oral mucosa irritation
発行日	2022-02-01
出版者	日本歯科理工学会(The Japanese Society for Dental Materials and Devices)
収録物名	Dental materials journal
巻(号)	41(1)
ページ	142-149
抄録	This study examined the controlled release of cetylpyridinium chloride (CPC) from a tissue conditioner (TC) containing CPC-montmorillonite (CPC-Mont), the associated antimicrobial activity, and oral mucosa irritation. The CPC release test was performed daily for 28 days in three test solutions: distilled water, 0.2 M NaCl, and 0.2 M HCl. The antimicrobial activities for 7, 14, 21, and 28 days against Candida albicans, Staphylococcus aureus, and Streptococcus mutans were assessed according to the JIS Z 2801/ISO 22196 standard. An oral mucosa irritation test was conducted using cheek pouches in five male hamsters according to the ISO 1099310:2010 standard. The amount of CPC released each day and the cumulative amount released over 28 days (6.12 mg) were less than the daily safe maximum of sore throat medicines (8 mg). Additionally, TC with CPC-Mont could sustain antimicrobial activity against adherent bacteria for 14 days and has no oral mucosa irritation potential.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0287-4547
関連情報	PMID 34556596
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.4012/dmj.2021-155