Secretion of GLP-1 but not GIP is potently stimulated by luminal d -Allulose ( d -Psicose) in rats

Hayakawa, Masaki; Hira, Tohru; Nakamura, Masako; Iida, Tetsuo; Kishimoto, Yuka; Hara, Hiroshi

Secretion of GLP-1 but not GIP is potently stimulated by luminal d -Allulose ( d -Psicose) in rats

Hayakawa, Masaki; Hira, Tohru; Nakamura, Masako et al.

Biochemical and Biophysical Research Communications, 2018, 496(3), 898-903

Permalink : https://hdl.handle.net/2115/85108

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アクセス権	open access
URI	https://hdl.handle.net/2115/85108
タイトル	Secretion of GLP-1 but not GIP is potently stimulated by luminal d -Allulose ( d -Psicose) in rats
著者	Hayakawa, Masaki ; Hira, Tohru ; Nakamura, Masako ; Iida, Tetsuo ; Kishimoto, Yuka ; Hara, Hiroshi
著者名 Hayakawa, Masaki
e-Rad_Researcher 10396301 著者名 Hira, Tohru
著者名 Nakamura, Masako
著者名 Iida, Tetsuo
著者名 Kishimoto, Yuka
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
言語	英語
キーワード	GLP-1
	GIP
	Allulose
発行日	2018-02-12
収録物名	Biochemical and Biophysical Research Communications
巻(号)	496(3)
ページ	898-903
抄録	Glucagon-like peptide 1 (GLP-1), an incretin gastrointestinal hormone, is secreted when stimulated by nutrients including metabolizable sugars such as glucose and fructose. d-Allulose (allulose), also known as d-psicose, is a C-3 isomer of d-fructose and a rare sugar with anti-diabetic or anti-obese effects in animal models. In the present study, we examined whether an oral administration of allulose could stimulate GLP-1 secretion in rats, and investigated the underlying mechanisms. Oral, but not intraperitoneal, administration of allulose (0.5?2.0?g/kg body weight) elevated plasma GLP-1 levels for more than 2?h in a dose-dependent manner. The effects of allulose on GLP-1 secretion were higher than that of dextrin, fructose, or glucose. In addition, oral allulose increased total and active GLP-1, but not glucose-dependent insulinotropic polypeptide (GIP), levels in the portal vein. In anesthetized rats equipped with a portal catheter, luminal (duodenum and ileum) administration of allulose increased portal GLP-1 levels, indicating the luminal effect of allulose. Allulose-induced GLP-1 secretion was abolished in the presence of xanthohumol (a glucose/fructose transport inhibitor), but not in the presence of inhibitors of the sodium-dependent glucose cotransporter 1 or the sweet taste receptor. These results demonstrate a potent and lasting effect of orally administered allulose on GLP-1 secretion in rats, without affecting GIP secretion. The potent and selective GLP-1-releasing effect of allulose holds promise for the prevention and treatment of glucose intolerance through promoting endogenous GLP-1 secretion.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0006-291X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2018.01.128