Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats

Chen, Wenya; Hira, Tohru; Nakajima, Shingo et al.

Bioscience, Biotechnology, and Biochemistry, 2018, 82(11), 1992-1999

Permalink : https://hdl.handle.net/2115/85125

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アクセス権
open access
URI
https://hdl.handle.net/2115/85125
タイトル
Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats
著者
Chen, Wenya ; Hira, Tohru ; Nakajima, Shingo ; Hara, Hiroshi
著者名
Chen, Wenya
e-Rad_Researcher
10396301
著者名
Hira, Tohru
著者名
Nakajima, Shingo
e-Rad_Researcher
70198894
著者名
Hara, Hiroshi
言語
英語
キーワード
Protein hydrolysate
gut satiety hormone
food intake
enteroendocrine cell
発行日
2018
収録物名
Bioscience, Biotechnology, and Biochemistry
巻(号)
82(11)
ページ
1992-1999
抄録
The study was aimed to compare the satiating effect of various protein hydrolysates in rats and examine the underlying mechanism associated with the satiety hormones. Food intake and portal satiety hormone levels were measured in rats. Enteroendocrine cell-lines were employed to study the direct effect of protein hydrolysates on gut hormone secretions. The results showed that oral preload of wheat gluten hydrolysate (WGH) suppressed food intake greater and longer than other hydrolysates. The portal peptide-YY levels in WGH-treated rats at 2 h and 3 h were higher than those in control- and lactalbumin hydrolysate (LAH)-treated rats. In a distal enteroendocrine cell model, WGH more potently stimulated glucagon-like peptide-1 secretion than LAH, and the effect was largely enhanced by pepsin/pancreatin digestion of WGH. These results suggest WGH is potent in activating enteroendocrine cells to release satiety hormones leading to the prolonged suppression of food intake.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Wenya Chen, Tohru Hira, Shingo Nakajima, Hiroshi Hara, Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats, Bioscience, Biotechnology, and Biochemistry, Volume 82, Issue 11, 2 November 2018, Pages 1992-1999 is available online at: https://doi.org/10.1080/09168451.2018.1505482.
PISSN
0916-8451
EISSN
1347-6947
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1080/09168451.2018.1505482